GstO2 Glutathione S transferase O2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: GstO2provided by FlyBase
Official Full Name: Glutathione S transferase O2provided by FlyBase
Primary source: FLYBASE:FBgn0035906
Locus tag: Dmel_CG6673
See related: AllianceGenome:FB:FBgn0035906
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Posey29; CG6673; CG6673-A; CG6673-B; CG6673A; CG6673B; Dmel\CG6673; DmGSTO1; DmGSTO2a; DmGSTO2b; gsto2; GSTO2; GSTO2a; GSTO2b
Summary: Enables several functions, including glutathione binding activity; glutathione dehydrogenase (ascorbate) activity; and glutathione transferase activity. Involved in glutathione metabolic process. Located in mitochondrion. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval garland cell; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Orthologous to human GSTO1 (glutathione S-transferase omega 1) and GSTO2 (glutathione S-transferase omega 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 66D5-66D5; 3-26 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8521429..8523501, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8514529..8516601, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the function of GstO2 is regulated by the PINK1/parkin pathway and GstO2 may also have a protective role in PINK1-associated Parkinson's disease
Title: Glutathione S-transferase omega suppresses the defective phenotypes caused by PINK1 loss-of-function in Drosophila.
Results suggest a novel mechanism for the protective role of DmGSTO1 (CG6673) in parkin mutants, through the regulation of ATP synthase activity, and provide insight into potential therapies for Parkinson disease neurodegeneration.
Title: Glutathione s-transferase omega 1 activity is sufficient to suppress neurodegeneration in a Drosophila model of Parkinson disease.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables glutathione dehydrogenase (ascorbate) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione dehydrogenase (ascorbate) activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
NOT enables pyrimidodiazepine synthase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	HMP more info	PubMed
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of innate immune response	HMP more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glutathione S transferase O2

Names: CG6673-PA; CG6673-PB; GstO2-PA; GstO2-PB

NP_648236.1

EC 1.8.5.1

EC 2.5.1.18

NP_729388.1

EC 1.8.5.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

8521429..8523501 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_168277.2 → NP_729388.1 glutathione S transferase O2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729388.1

Status: REVIEWED

UniProtKB/TrEMBL

Q29QZ8, Q9VSL5

Related

FBpp0076378

Conserved Domains (3) summary

cd03184
Location:110 → 235

GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases

COG0625
Location:25 → 215

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

cl00388
Location:5 → 96

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
NM_139979.3 → NP_648236.1 glutathione S transferase O2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648236.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7K206, Q95RJ2, Q9VSL4

Related

FBpp0076377

Conserved Domains (3) summary

cd03184
Location:111 → 236

GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases

COG0625
Location:23 → 232

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

cl00388
Location:5 → 96

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold