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    Dic61B Dynein intermediate chain at 61B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38020, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dic61Bprovided by FlyBase
    Official Full Name
    Dynein intermediate chain at 61Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263988
    Locus tag
    Dmel_CG7051
    See related
    AllianceGenome:FB:FBgn0263988
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7051; Dmel\CG7051; ms; ms(3)21
    Summary
    Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Involved in cilium movement and spermatogenesis. Part of axonemal dynein complex. Is expressed in spermatogonium; spermatozoon; and testis. Orthologous to human DNAI4 (dynein axonemal intermediate chain 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dic61B in Genome Data Viewer
    Location:
    61B1-61B1; 3-1 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (149679..152589, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (149679..152589, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45805 Neighboring gene Phosphoinositide-dependent kinase 1 Neighboring gene uncharacterized protein Neighboring gene p130CAS Neighboring gene long non-coding RNA:CR43151 Neighboring gene antisense RNA:CR45806 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Dynein intermediate chain gene, Dic61B, is required for spermatogenesis. Fatima R. PLoS One, 2011. PMID 22145020, Free PMC Article
    2. The hsromega(05241) allele of the noncoding hsromega gene of Drosophila melanogaster is not responsible for male sterility as reported earlier. Akanksha, et al. J Genet, 2008 Apr. PMID 18560179
    3. Altered expressions of the noncoding hsromega gene enhances poly-Q-induced neurotoxicity in Drosophila. Sengupta S, et al. RNA Biol, 2006 Jan-Mar. PMID 17114940
    4. Male sterility associated with overexpression of the noncoding hsromega gene in cyst cells of testis of Drosophila melanogaster. Rajendra TK, et al. J Genet, 2001 Aug. PMID 11910129
    5. Diverse Roles of Axonemal Dyneins in Drosophila Auditory Neuron Function and Mechanical Amplification in Hearing. Karak S, et al. Sci Rep, 2015 Nov 26. PMID 26608786, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium movement IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of axonemal dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of axonemal dynein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynein intermediate chain at 61B
    Names
    CG7051-PA
    CG7051-PB
    Dic61B-PA
    Dic61B-PB
    male sterile (3) 21

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      149679..152589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167796.3 → NP_728477.1  dynein intermediate chain at 61B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728477.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGZ6, Q9W0U9
      Related
      FBpp0072438
      Conserved Domains (3) summary
      COG2319
      Location:358 → 730
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:604 → 637
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:433 → 711
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_138157.3 → NP_612001.1  dynein intermediate chain at 61B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612001.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGZ6, Q8T0V3
      Related
      FBpp0072437
      Conserved Domains (3) summary
      COG2319
      Location:278 → 650
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:524 → 557
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:353 → 631
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGZ6 Q8IGZ6
    Q8T0V3 Q8T0V3
    Q9W0U9 Q9W0U9

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