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    Npl4 Nuclear protein localization 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43091, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Npl4provided by FlyBase
    Official Full Name
    Nuclear protein localization 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0039348
    Locus tag
    Dmel_CG4673
    See related
    AllianceGenome:FB:FBgn0039348
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4673; Dmel\CG4673; dNp14; dNpl4; dNPLOC4; npl4; NPL4
    Summary
    Enables K11-linked polyubiquitin modification-dependent protein binding activity. Involved in cellular response to virus; negative regulation of smoothened signaling pathway; and ubiquitin-dependent protein catabolic process. Located in cytosol and nucleoplasm. Is expressed in several structures, including adult brain cell body rind; adult gnathal ganglion; adult head; adult heart; and synaptic neuropil domain. Used to study neurodegenerative disease. Orthologous to human NPLOC4 (NPL4 homolog, ubiquitin recognition factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Npl4 in Genome Data Viewer
    Location:
    96E4-96E6; 3-88 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25611013..25624662, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21436735..21450384, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene musashi Neighboring gene long non-coding RNA:CR45910 Neighboring gene mir-1000 stem loop Neighboring gene yellow-emperor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Succinic semialdehyde dehydrogenase Neighboring gene jing interacting gene regulatory 1 Neighboring gene mir-92a stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles for the VCP co-factors Npl4 and Ufd1 in neuronal function in Drosophila melanogaster. Byrne DJ, et al. J Genet Genomics, 2017 Oct 20. PMID 29037990, Free PMC Article
    2. Genome-wide RNAi screen identifies SEC61A and VCP as conserved regulators of Sindbis virus entry. Panda D, et al. Cell Rep, 2013 Dec 26. PMID 24332855, Free PMC Article
    3. RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis. Wójcik C, et al. J Cell Sci, 2004 Jan 15. PMID 14657277
    4. Segmental duplication, microinversion, and gene loss associated with a complex inversion breakpoint region in Drosophila. Calvete O, et al. Mol Biol Evol, 2012 Jul. PMID 22328714, Free PMC Article
    5. Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration. Avery MA, et al. J Cell Biol, 2009 Feb 23. PMID 19237597, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. differing neuronal functions of Npl4 and Ufd1 in vivo
      Title: Roles for the VCP co-factors Npl4 and Ufd1 in neuronal function in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables K11-linked polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in nucleoplasm HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nuclear protein localization 4
    Names
    CG4673-PA
    CG4673-PB
    CG4673-PD
    Npl4 ortholog
    Npl4-PA
    Npl4-PB
    Npl4-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25611013..25624662 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170231.3 → NP_733110.2  nuclear protein localization 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733110.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VBP9
      Conserved Domains (6) summary
      smart00547
      Location:599 → 623
      ZnF_RBZ; Zinc finger domain
      COG5100
      Location:6 → 527
      NPL4; Nuclear pore protein [Nuclear structure]
      sd00029
      Location:601 → 620
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam05020
      Location:113 → 251
      zf-NPL4; NPL4 family, putative zinc binding region
      pfam05021
      Location:254 → 565
      NPL4; NPL4 family
      pfam11543
      Location:5 → 78
      UN_NPL4; Nuclear pore localization protein NPL4

    2. NM_001170260.2 → NP_001163731.1  nuclear protein localization 4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163731.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VBP9
      Conserved Domains (6) summary
      smart00547
      Location:599 → 623
      ZnF_RBZ; Zinc finger domain
      COG5100
      Location:6 → 527
      NPL4; Nuclear pore protein [Nuclear structure]
      sd00029
      Location:601 → 620
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam05020
      Location:113 → 251
      zf-NPL4; NPL4 family, putative zinc binding region
      pfam05021
      Location:254 → 565
      NPL4; NPL4 family
      pfam11543
      Location:5 → 78
      UN_NPL4; Nuclear pore localization protein NPL4

    3. NM_143150.4 → NP_651407.3  nuclear protein localization 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651407.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C9QPJ1, E1JIX5, H8F4R9, Q8IMS6, Q95U63, Q9VBP9
      Conserved Domains (6) summary
      smart00547
      Location:627 → 651
      ZnF_RBZ; Zinc finger domain
      COG5100
      Location:35 → 555
      NPL4; Nuclear pore protein [Nuclear structure]
      sd00029
      Location:629 → 648
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam05020
      Location:141 → 279
      zf-NPL4; NPL4 family, putative zinc binding region
      pfam05021
      Location:282 → 593
      NPL4; NPL4 family
      pfam11543
      Location:33 → 106
      UN_NPL4; Nuclear pore localization protein NPL4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBP9.3 Q9VBP9

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