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    Dlic Dynein light intermediate chain [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32057, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dlicprovided by FlyBase
    Official Full Name
    Dynein light intermediate chainprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030276
    Locus tag
    Dmel_CG1938
    See related
    AllianceGenome:FB:FBgn0030276
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1938; D-LIC; dlic; DLIC; dlic2; Dlic2; DLIC2; Dmel\CG1938; l(1)G0065; l(1)G0190
    Summary
    Predicted to enable dynein heavy chain binding activity. Involved in several processes, including lumen formation, open tracheal system; mRNA transport; and neuron projection morphogenesis. Located in cytoplasm. Part of cytoplasmic dynein complex. Colocalizes with centrosome and nuclear envelope. Is expressed in adult head; oocyte; and organism. Orthologous to human DYNC1LI1 (dynein cytoplasmic 1 light intermediate chain 1) and DYNC1LI2 (dynein cytoplasmic 1 light intermediate chain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dlic in Genome Data Viewer
    Location:
    10A8-10A8; 1-33 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11154421..11164670)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11048454..11058703)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ran Neighboring gene l(3)mbt interacting protein 1 Neighboring gene retroactive Neighboring gene uncharacterized protein Neighboring gene Antennal dehydrogenase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DLIC1, but not DLIC2, is upregulated in colon cancer and this contributes to proliferative overgrowth and migratory characteristics of cancer cells. Even I, et al. FEBS J, 2019 Feb. PMID 30657258
    2. The influence of dynein processivity control, MAPs, and microtubule ends on directional movement of a localising mRNA. Soundararajan HC, et al. Elife, 2014 Apr 15. PMID 24737859, Free PMC Article
    3. A central neural pathway controlling odor tracking in Drosophila. Slater G, et al. J Neurosci, 2015 Feb 4. PMID 25653345, Free PMC Article
    4. Mutations in the Drosophila rough deal gene affecting RZZ kinetochore function. Menant A, et al. Biol Cell, 2020 Oct. PMID 32602944
    5. Single-molecule assays reveal that RNA localization signals regulate dynein-dynactin copy number on individual transcript cargoes. Amrute-Nayak M, et al. Nat Cell Biol, 2012 Feb 26. PMID 22366687, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results point to a connection between membrane trafficking and dynein-mediated transport to sustain PAR3 asymmetry.
      Title: Dynein-mediated transport and membrane trafficking control PAR3 polarised distribution.
    2. RNA interference depletion of Dlic in Drosophila S2 cells does not block the recruitment of a dynein complex to kinetochores, but it does delay inactivation of Mad2 signaling and mitotic progression.
      Title: Dynein light intermediate chain: an essential subunit that contributes to spindle checkpoint inactivation.
    3. These results reveal an important link between microtubule motors and endosomes in dendrite morphogenesis.
      Title: Spatial control of branching within dendritic arbors by dynein-dependent transport of Rab5-endosomes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein heavy chain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in axo-dendritic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lumen formation, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle HMP PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytoplasmic dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    colocalizes_with nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynein light intermediate chain
    Names
    CG1938-PA
    CG1938-PB
    CG1938-PD
    Dlic-PA
    Dlic-PB
    Dlic-PD
    Dlic2
    DyneinLC
    dandelion clock
    dynein light interme- diate chain
    dynein light intermediate chain 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11154421..11164670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167274.2 → NP_727501.1  dynein light intermediate chain, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727501.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U53, Q9VZ20
      Related
      FBpp0073299
      Conserved Domains (2) summary
      cd00267
      Location:43 → 79
      ABC_ATPase; ATP-binding cassette transporter nucleotide-binding domain
      pfam05783
      Location:25 → 493
      DLIC; Dynein light intermediate chain (DLIC)

    2. NM_132466.3 → NP_572694.1  dynein light intermediate chain, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572694.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U53, Q9VZ20
      Related
      FBpp0073297
      Conserved Domains (2) summary
      cd00267
      Location:43 → 79
      ABC_ATPase; ATP-binding cassette transporter nucleotide-binding domain
      pfam05783
      Location:25 → 493
      DLIC; Dynein light intermediate chain (DLIC)

    3. NM_167276.2 → NP_727503.1  dynein light intermediate chain, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727503.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IR93
      Related
      FBpp0073300
      Conserved Domains (1) summary
      pfam05783
      Location:1 → 398
      DLIC; Dynein light intermediate chain (DLIC)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IR93 Q8IR93
    Q9VZ20 Q9VZ20

    Gene LinkOut

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