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    GXIVsPLA2 GXIVsPLA2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39734, updated on 17-Dec-2024

    Summary

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    Official Symbol
    GXIVsPLA2provided by FlyBase
    Official Full Name
    GXIVsPLA2provided by FlyBase
    Primary source
    FLYBASE:FBgn0036545
    Locus tag
    Dmel_CG17035
    See related
    AllianceGenome:FB:FBgn0036545
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17035; Dmel\CG17035; GXIVsPLA
    Summary
    Predicted to enable calcium ion binding activity and phospholipase A2 activity. Predicted to be involved in arachidonate secretion; lipid catabolic process; and phospholipid metabolic process. Predicted to be located in extracellular region. Is expressed in adult head; foregut anlage in statu nascendi; and organism. Orthologous to human PLA2G12A (phospholipase A2 group XIIA) and PLA2G12B (phospholipase A2 group XIIB). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GXIVsPLA2 in Genome Data Viewer
    Location:
    72B2-72B2; 3-43 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15955096..15956465)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15948196..15949565)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene sugar-free frosting Neighboring gene Protein kinase, cAMP-dependent, catalytic subunit 3 Neighboring gene uncharacterized protein Neighboring gene early girl

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila spermatid individualization is sensitive to temperature and fatty acid metabolism. Ben-David G, et al. Spermatogenesis, 2015 Jan-Apr. PMID 26413411, Free PMC Article
    2. PI3K/Akt Cooperates with Oncogenic Notch by Inducing Nitric Oxide-Dependent Inflammation. Villegas SN, et al. Cell Rep, 2018 Mar 6. PMID 29514083
    3. PLA2G12A as a Novel Biomarker for Colorectal Cancer with Prognostic Relevance. Parisi E, et al. Int J Mol Sci, 2023 Jun 30. PMID 37446068, Free PMC Article
    4. Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila. Qurashi A, et al. Hum Mol Genet, 2012 May 1. PMID 22298836, Free PMC Article
    5. Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogaster. Jumbo-Lucioni P, et al. BMC Genomics, 2010 May 11. PMID 20459830, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent phospholipase A2 activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GXIVsPLA2
    Names
    CG17035-PA
    CG17035-PC
    CG17035-PD
    GXIVsPLA2-PA
    GXIVsPLA2-PC
    GXIVsPLA2-PD
    NP_001137957.1
    NP_001261903.1
    NP_648815.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15955096..15956465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274974.1 → NP_001261903.1  GXIVsPLA2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261903.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BIV5, Q9VUV6
      Conserved Domains (1) summary
      cl29745
      Location:18 → 199
      Phospholip_A2_3; Prokaryotic phospholipase A2

    2. NM_001144485.3 → NP_001137957.1  GXIVsPLA2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137957.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z059

    3. NM_140558.4 → NP_648815.1  GXIVsPLA2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648815.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BIV5, Q9VUV6
      Related
      FBpp0075264
      Conserved Domains (1) summary
      cl29745
      Location:18 → 199
      Phospholip_A2_3; Prokaryotic phospholipase A2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z059 B7Z059
    Q9VUV6 Q9VUV6

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