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    CG13630 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42943, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG13630provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039219
    Locus tag
    Dmel_CG13630
    See related
    AllianceGenome:FB:FBgn0039219
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG13630; MAP1A
    Summary
    Predicted to enable metalloaminopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in cytosol. Is expressed in adult head. Orthologous to human METAP1 (methionyl aminopeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG13630 in Genome Data Viewer
    Location:
    96A18-96A18; 3-85 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24717937..24719364, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20543659..20545086, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene slowpoke Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene RNA polymerase II, I and III subunit L Neighboring gene tolkin Neighboring gene tolloid

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms. Giglione C, et al. EMBO J, 2000 Nov 1. PMID 11060042, Free PMC Article
    2. Proteogenomics of Adenosine-to-Inosine RNA Editing in the Fruit Fly. Kuznetsova KG, et al. J Proteome Res, 2018 Nov 2. PMID 30298734
    3. Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster. Zdobnov EM, et al. Science, 2002 Oct 4. PMID 12364792
    4. Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover. Huang S, et al. PLoS Biol, 2013 Nov. PMID 24302888, Free PMC Article
    5. Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments. Page RM, et al. J Neurosci, 2012 Dec 12. PMID 23238734, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG13630-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24717937..24719364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143024.3 → NP_651281.1  uncharacterized protein Dmel_CG13630 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651281.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VC48
      Related
      FBpp0084120
      Conserved Domains (3) summary
      PLN03158
      Location:10 → 369
      PLN03158; methionine aminopeptidase; Provisional
      cd01086
      Location:123 → 360
      MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
      pfam15801
      Location:9 → 48
      zf-C6H2; zf-MYND-like zinc finger, mRNA-binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VC48 Q9VC48

    Gene LinkOut

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