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    GluRIIC Glutamate receptor IIC [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33275, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GluRIICprovided by FlyBase
    Official Full Name
    Glutamate receptor IICprovided by FlyBase
    Primary source
    FLYBASE:FBgn0046113
    Locus tag
    Dmel_CG4226
    See related
    AllianceGenome:FB:FBgn0046113
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4226; CT13021; DGluR-IIC; DGluRIIC; DGluRIII; DmelGluRIIC; Dmel\CG4226; GluR; GluR3; GluRC; GluRII-C; GluRIIc; GLURIIC; GluRIIC/III; GluRIII; GLURIII; glutamate receptor III; GlutRIII
    Summary
    Enables glutamate-gated calcium ion channel activity. Involved in calcium ion transport; establishment of protein localization; and neuromuscular synaptic transmission. Located in muscle cell postsynaptic specialization. Part of ionotropic glutamate receptor complex. Is expressed in several structures, including embryonic ventral epidermis; embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval neuromuscular junction; and muscle cell. Orthologous to human GRIK4 (glutamate ionotropic receptor kainate type subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GluRIIC in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (914086..917805)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (914086..917805)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45261 Neighboring gene long non-coding RNA:CR44061 Neighboring gene Transmembrane O-mannosyltransferase targeting cadherins 2 Neighboring gene long non-coding RNA:CR44801

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Investigating the safety factor at an invertebrate neuromuscular junction. Marrus SB, et al. J Neurobiol, 2005 Apr. PMID 15685612
    2. Preferential localization of glutamate receptors opposite sites of high presynaptic release. Marrus SB, et al. Curr Biol, 2004 Jun 8. PMID 15182665
    3. Structural Remodeling of Active Zones Is Associated with Synaptic Homeostasis. Hong H, et al. J Neurosci, 2020 Apr 1. PMID 32122953, Free PMC Article
    4. The development of motor coordination in Drosophila embryos. Crisp S, et al. Development, 2008 Nov. PMID 18927150, Free PMC Article
    5. Structure-function analysis of endogenous lectin mind-the-gap in synaptogenesis. Rushton E, et al. Dev Neurobiol, 2012 Aug. PMID 22234957, Free PMC Article

    See all (162) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables glutamate-gated calcium ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate-gated receptor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables kainate selective glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuromuscular synaptic transmission IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic transmission, glutamatergic IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ionotropic glutamate receptor complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in muscle cell postsynaptic specialization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate receptor IIC
    Names
    CG4226-PD
    GluRIIC-PD
    common type III glutamate receptor subunit
    essential glutamate receptor subunit III
    glutamate receptor
    glutamate receptor III
    glutamate receptor subunit III

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      914086..917805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134713.4 → NP_608557.4  glutamate receptor IIC [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608557.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DMP9, Q9VPV3
      Conserved Domains (4) summary
      cd06382
      Location:26 → 404
      PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
      cd13714
      Location:423 → 794
      PBP2_iGluR_Kainate; Kainate receptor of the type 2 periplasmic-binding fold superfamily
      pfam00060
      Location:554 → 828
      Lig_chan; Ligand-gated ion channel
      cl10011
      Location:279 → 363
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T0K9 Q8T0K9
    Q9VPV3 Q9VPV3

    Gene LinkOut

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