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    D19A D19A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38718, updated on 9-Dec-2024

    Summary

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    Official Symbol
    D19Aprovided by FlyBase
    Official Full Name
    D19Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0022935
    Locus tag
    Dmel_CG10269
    See related
    AllianceGenome:FB:FBgn0022935
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10269; d19a; Dmel\CG10269
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in several structures, including dorsal epidermis primordium; embryonic dorsal epidermis; ganglia; gut section; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See D19A in Genome Data Viewer
    Location:
    65A7-65A7; 3-16 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6185830..6189123, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6178930..6182223, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene D19B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Splicing factor 3b subunit 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AT-hook motifs identified in a wide variety of DNA-binding proteins. Aravind L, et al. Nucleic Acids Res, 1998 Oct 1. PMID 9742243, Free PMC Article
    2. Structural basis of diversity and homodimerization specificity of zinc-finger-associated domains in Drosophila. Bonchuk A, et al. Nucleic Acids Res, 2021 Feb 26. PMID 33638995, Free PMC Article
    3. Identification of chromatin-associated regulators of MSL complex targeting in Drosophila dosage compensation. Larschan E, et al. PLoS Genet, 2012. PMID 22844249, Free PMC Article
    4. Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA). Housden BE, et al. Proc Natl Acad Sci U S A, 2017 Dec 12. PMID 29183982, Free PMC Article
    5. Genomic expansion and clustering of ZAD-containing C2H2 zinc-finger genes in Drosophila. Chung HR, et al. EMBO Rep, 2002 Dec. PMID 12446571, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D19A
    Names
    CG10269-PA
    D19A-PA
    zinc finger AT-hook protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6185830..6189123 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057956.4 → NP_477304.1  D19A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477304.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18401, Q9VRV5
      Related
      FBpp0076724
      Conserved Domains (4) summary
      smart00868
      Location:12 → 83
      zf-AD; Zinc-finger associated domain (zf-AD)
      TIGR02794
      Location:724 → 814
      tolA_full; TolA protein
      sd00017
      Location:652 → 673
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:694 → 718
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18401 O18401
    Q8T0K6 Q8T0K6
    Q9VRV5 Q9VRV5

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