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    Hydr1 alpha/beta hydrolase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35930, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hydr1provided by FlyBase
    Official Full Name
    alpha/beta hydrolase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033382
    Locus tag
    Dmel_CG8058
    See related
    AllianceGenome:FB:FBgn0033382
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8058; Dm.HYDR1; Dmel\CG8058
    Summary
    Predicted to enable acetylesterase activity and monoacylglycerol lipase activity. Predicted to be involved in medium-chain fatty acid biosynthetic process and medium-chain fatty acid catabolic process. Is expressed in adult head. Orthologous to human ABHD1 (abhydrolase domain containing 1) and ABHD3 (abhydrolase domain containing 3, phospholipase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Hydr1 in Genome Data Viewer
    Location:
    45A11-45A11; 2-60 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9132480..9135453)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5019985..5022958)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Suppressor of variegation 2-10 Neighboring gene Glutathione S transferase E13 Neighboring gene uncharacterized protein Neighboring gene alicorn Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene shrub

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetylesterase activity  
    enables lipase activity PubMed 
    enables monoacylglycerol lipase activity  
    Component Evidence Code Pubs
    is_active_in cellular_component  

    General protein information

    Preferred Names
    alpha/beta hydrolase 1
    Names
    CG8058-PA
    CG8058-PB
    CG8058-PC
    CG8058-PD
    CG8058-PE
    Hydr1-PA
    Hydr1-PB
    Hydr1-PC
    Hydr1-PD
    Hydr1-PE
    NP_001188892.1
    NP_001286229.1
    NP_001286230.1
    NP_610459.2
    NP_724757.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9132480..9135453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299300.1 → NP_001286229.1  alpha/beta hydrolase 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286229.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2QCN3, Q95S61
      Conserved Domains (2) summary
      pfam00561
      Location:119 → 366
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:53 → 368
      Abhydrolase; alpha/beta hydrolases
    2. NM_001201963.2 → NP_001188892.1  alpha/beta hydrolase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188892.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7Q7, Q95S61
      Conserved Domains (2) summary
      pfam00561
      Location:206 → 453
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:140 → 455
      Abhydrolase; alpha/beta hydrolases
    3. NM_165653.3 → NP_724757.2  alpha/beta hydrolase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724757.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2QCN3, Q95S61
      Conserved Domains (2) summary
      pfam00561
      Location:119 → 366
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:53 → 368
      Abhydrolase; alpha/beta hydrolases
    4. NM_136615.4 → NP_610459.2  alpha/beta hydrolase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610459.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7Q7, Q95S61
      Related
      FBpp0087661
      Conserved Domains (2) summary
      pfam00561
      Location:206 → 453
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:140 → 455
      Abhydrolase; alpha/beta hydrolases
    5. NM_001299301.1 → NP_001286230.1  alpha/beta hydrolase 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286230.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2QCN3, Q95S61
      Conserved Domains (2) summary
      pfam00561
      Location:119 → 366
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:53 → 368
      Abhydrolase; alpha/beta hydrolases
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