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    Nop56 Nop56 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42633, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nop56provided by FlyBase
    Official Full Name
    Nop56provided by FlyBase
    Primary source
    FLYBASE:FBgn0038964
    Locus tag
    Dmel_CG13849
    See related
    AllianceGenome:FB:FBgn0038964
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13849; Dmel\CG13849; DmNop56; Dnop56; nop56
    Summary
    Predicted to enable snoRNA binding activity. Predicted to be involved in rRNA processing. Predicted to be part of box C/D methylation guide snoRNP complex and small-subunit processome. Is expressed in several structures, including adult head; adult heart; lamina; lamina anlage; and stem cell. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 36. Orthologous to human NOP56 (NOP56 ribonucleoprotein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nop56 in Genome Data Viewer
    Location:
    94A12-94A12; 3-74 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22419095..22421068, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18244817..18246790, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene liquid facets-Related Neighboring gene mob as tumor suppressor Neighboring gene prolonged depolarization afterpotential (PDA) is not apparent

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dnop56, a Drosophila gene homologous to the yeast nucleolar NOP56 gene. García-Planells J, et al. Genetica, 2000. PMID 11430491
    2. RNA-binding protein hoip accelerates polyQ-induced neurodegeneration in Drosophila. Murata T, et al. Biosci Biotechnol Biochem, 2008 Sep. PMID 18776683
    3. An RNAi screen for ribosome biogenesis genes required for Drosophila border cell collective migration. Burghardt E, et al. MicroPubl Biol, 2024. PMID 39185014, Free PMC Article
    4. Drosophila liquid facets-Related encodes Golgi epsin and is an essential gene required for cell proliferation, growth, and patterning. Lee JH, et al. Dev Biol, 2009 Jul 1. PMID 19376106, Free PMC Article
    5. Nucleolar stress in Drosophila neuroblasts, a model for human ribosomopathies. Baral SS, et al. Biol Open, 2020 Apr 13. PMID 32184230, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables snoRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables snoRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of box C/D methylation guide snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of box C/D methylation guide snoRNP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nop56
    Names
    CG13849-PA
    Nop56-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22419095..22421068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142783.2 → NP_651040.3  Nop56 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651040.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGT5, Q95WY3, Q9VD11
      Related
      FBpp0083625, FBtr0084230
      Conserved Domains (3) summary
      smart00931
      Location:169 → 220
      NOSIC; NOSIC (NUC001) domain
      COG1498
      Location:47 → 430
      SIK1; RNA processing factor Prp31, contains Nop domain [Translation, ribosomal structure and biogenesis]
      pfam08156
      Location:5 → 70
      NOP5NT; NOP5NT (NUC127) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGT5 Q8IGT5
    Q95WY3 Q95WY3
    Q95WY4 Q95WY4
    Q961E2 Q961E2

    Gene LinkOut

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