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    eEF1alpha1 eukaryotic translation elongation factor 1 alpha 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36271, updated on 17-Dec-2024

    Summary

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    Official Symbol
    eEF1alpha1provided by FlyBase
    Official Full Name
    eukaryotic translation elongation factor 1 alpha 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0284245
    Locus tag
    Dmel_CG8280
    See related
    AllianceGenome:FB:FBgn0284245
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0248; 1275; anon-EST:Liang-1.17; anon-EST:Liang-2.46; CG8280; chr2R:7409490..7409690; chr2R:7410009..7410129; clone 1.17; clone 2.46; Dm0084; DmEF1; Dmel\CG8280; eEF1a1; eEF1alpha; EF; EF-1; EF-1a; ef-1alpha; EF-1alpha; EF-1alpha F1; EF-1alphaF; EF-1alphaF1; EF-1alphaF[[1]]; EF-1[a]; Ef1; EF1; EF1-alpha; EF11_DROME; EF1A1; Ef1a10; Ef1a48D; EF1alpha; Ef1alpha 48D; EF1alpha 48D; Ef1alpha1; EF1alpha1; Ef1alpha48D; EF1alpha48D; Ef1alpha48E; Efalpha48D; F1; F1 EF-1alpha; l(2)00248; l(2)01275; l(2)1275; l(2)248; l(2)k07303
    Summary
    Predicted to enable GTPase activity and translation elongation factor activity. Involved in determination of adult lifespan. Predicted to be part of eukaryotic translation elongation factor 1 complex. Is expressed in several structures, including adult central complex; adult head; brain; glial cell; and imaginal disc. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 38; developmental and epileptic encephalopathy 33; and ovarian cancer. Orthologous to human EEF1A1 (eukaryotic translation elongation factor 1 alpha 1); EEF1A1P5 (eukaryotic translation elongation factor 1 alpha 1 pseudogene 5); and EEF1A2 (eukaryotic translation elongation factor 1 alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eEF1alpha1 in Genome Data Viewer
    Location:
    48C5-48C5; 2-65 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11891135..11895762)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7778640..7783267)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene cutoff Neighboring gene Endoplasmic reticulum p60 Neighboring gene Microcephalin Neighboring gene Zinc/iron regulated transporter-related protein 48C Neighboring gene rebuf

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Specific disappearance of translatable messenger RNA for elongation factor one in aging Drosophila melanogaster. Webster GC, et al. Mech Ageing Dev, 1984 Mar. PMID 6143864
    2. The effects of enhanced expression of elongation factor EF-1 alpha on lifespan in Drosophila melanogaster. IV. A summary of three experiments. Stearns SC, et al. Genetica, 1993. PMID 8125267
    3. Protein synthesis elongation factor EF-1 alpha expression and longevity in Drosophila melanogaster. Shikama N, et al. Proc Natl Acad Sci U S A, 1994 May 10. PMID 8183891, Free PMC Article
    4. A strong ubiquitous promoter-enhancer for development and aging of Drosophila melanogaster. Ackermann R, et al. Nucleic Acids Res, 1996 Jun 15. PMID 8710521, Free PMC Article
    5. Effects on fitness components of enhanced expression of elongation factor EF-1alpha in Drosophila melanogaster. I. The contrasting approaches of molecular and population biologists. Stearns SC, et al. Am Nat, 1993 Dec. PMID 19425944

    See all (153) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Efficient binding of ZADs from the proteins Grau, ZIPIC, and Zw5 to the translation elongation factor EF1alpha1 in nuclear and cytoplasmic extracts has been demonstrated.
      Title: [Translation elongation factor EF1α1 interacts with ZAD domains of transcription factors from Drosophila melanogaster].
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of eukaryotic translation elongation factor 1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation elongation factor 1 alpha 1
    Names
    CG8280-PA
    CG8280-PC
    CG8280-PD
    CG8280-PE
    Ef1 alpha 48D
    eEF1alpha1-PA
    eEF1alpha1-PC
    eEF1alpha1-PD
    eEF1alpha1-PE
    elongation factor 1 alpha
    elongation factor 1 alpha 48D
    elongation factor 1-alpha F1
    elongation factor 1alpha48D
    lethal (2) 00248
    translational elongation factor1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11891135..11895762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299393.1 → NP_001286322.1  eukaryotic translation elongation factor 1 alpha 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286322.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C6TP87, P08736, Q0E9B9, Q9V631
      Conserved Domains (1) summary
      PTZ00141
      Location:1 → 457
      PTZ00141; elongation factor 1- alpha; Provisional

    2. NM_165850.3 → NP_725085.1  eukaryotic translation elongation factor 1 alpha 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725085.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C6TP87, P08736, Q0E9B9, Q9V631
      Related
      FBpp0304260
      Conserved Domains (1) summary
      PTZ00141
      Location:1 → 457
      PTZ00141; elongation factor 1- alpha; Provisional

    3. NM_058027.5 → NP_477375.1  eukaryotic translation elongation factor 1 alpha 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477375.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C6TP87, P08736, Q0E9B9, Q9V631
      Related
      FBpp0087142
      Conserved Domains (1) summary
      PTZ00141
      Location:1 → 457
      PTZ00141; elongation factor 1- alpha; Provisional

    4. NM_001299392.1 → NP_001286321.1  eukaryotic translation elongation factor 1 alpha 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286321.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C6TP87, P08736, Q0E9B9, Q9V631
      Conserved Domains (1) summary
      PTZ00141
      Location:1 → 457
      PTZ00141; elongation factor 1- alpha; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08736.2 P08736
    Q8T3U3 Q8T3U3

    Gene LinkOut

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