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    CG4080 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39079, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4080provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035983
    Locus tag
    Dmel_CG4080
    See related
    AllianceGenome:FB:FBgn0035983
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4080; Dmel\CG4080
    Summary
    Predicted to enable MHC protein binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in antigen processing and presentation of peptide antigen via MHC class II; immune response; and protein polyubiquitination. Predicted to be located in plasma membrane. Predicted to be active in early endosome membrane; late endosome membrane; and lysosome. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; ganglia; and posterior endoderm. Orthologous to several human genes including MARCHF8 (membrane associated ring-CH-type finger 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4080 in Genome Data Viewer
    Location:
    67B3-67B4; 3-29 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9386827..9399227, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9379927..9392327, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Heat shock protein 27 Neighboring gene pseudo Neighboring gene pseudo Neighboring gene eukaryotic translation initiation factor 4E1 Neighboring gene Cuticular protein 67B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the shsp genes in Drosophila buzzatii and association between the frequency of Valine mutations in hsp23 and climatic variables along a longitudinal gradient in Australia. Frydenberg J, et al. Cell Stress Chaperones, 2010 May. PMID 19806471, Free PMC Article
    2. Timing and targeting of P-element local transposition in the male germline cells of Drosophila melanogaster. Timakov B, et al. Genetics, 2002 Mar. PMID 11901118, Free PMC Article
    3. The conserved Pelado/ZSWIM8 protein regulates actin dynamics by promoting linear actin filament polymerization. Molina-Pelayo C, et al. Life Sci Alliance, 2022 Aug 8. PMID 35940847, Free PMC Article
    4. Transcriptional targets of Drosophila JAK/STAT pathway signalling as effectors of haematopoietic tumour formation. Bina S, et al. EMBO Rep, 2010 Mar. PMID 20168330, Free PMC Article
    5. The T-box-encoding Dorsocross genes function in amnioserosa development and the patterning of the dorsolateral germ band downstream of Dpp. Reim I, et al. Development, 2003 Jul. PMID 12783790

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables MHC protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of peptide antigen via MHC class II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4080-PA
    CG4080-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9386827..9399227 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259766.2 → NP_001246695.1  uncharacterized protein Dmel_CG4080, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246695.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSX7
      Conserved Domains (1) summary
      smart00744
      Location:42 → 90
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    2. NM_140048.3 → NP_648305.1  uncharacterized protein Dmel_CG4080, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648305.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSX7
      Related
      FBpp0076222
      Conserved Domains (1) summary
      smart00744
      Location:42 → 90
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VSX7 Q9VSX7

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