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    CG12746 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40672, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12746provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037341
    Locus tag
    Dmel_CG12746
    See related
    AllianceGenome:FB:FBgn0037341
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12746; WUN-like
    Summary
    Predicted to enable diacylglycerol diphosphate phosphatase activity and phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation and phospholipid metabolic process. Predicted to be active in membrane. Is expressed in several structures, including adult head; embryonic large intestine; embryonic/larval posterior spiracle; and gut section. Orthologous to human PLPP4 (phospholipid phosphatase 4) and PLPP5 (phospholipid phosphatase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12746 in Genome Data Viewer
    Location:
    83B2-83B2; 3-47.5 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5564865..5567435)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1390587..1393157)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol 4-kinase II alpha Neighboring gene antisense RNA:CR46136 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ras homolog enriched in brain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular organization of Drosophila neuroendocrine cells by Dimmed. Park D, et al. Curr Biol, 2011 Sep 27. PMID 21885285, Free PMC Article
    2. Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis. Sanchez-Alvarez M, et al. Open Biol, 2015 Sep. PMID 26333836, Free PMC Article
    3. A role for triglyceride lipase brummer in the regulation of sex differences in Drosophila fat storage and breakdown. Wat LW, et al. PLoS Biol, 2020 Jan. PMID 31961851, Free PMC Article
    4. Metabolism of sphingosine 1-phosphate and lysophosphatidic acid: a genome wide analysis of gene expression in Drosophila. Renault AD, et al. Mech Dev, 2002 Dec. PMID 14516700
    5. Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. Horn T, et al. Nat Methods, 2011 Apr. PMID 21378980

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables diacylglycerol diphosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12746-PB
    CG12746-PD
    CG12746-PE
    PPAPDC1
    NP_649551.4
    NP_730949.2
    NP_788583.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5564865..5567435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176406.4 → NP_788583.1  uncharacterized protein Dmel_CG12746, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788583.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGV3, Q8IPQ4
      Related
      FBpp0078341
      Conserved Domains (1) summary
      cd03390
      Location:104 → 302
      PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

    2. NM_169067.5 → NP_730949.2  uncharacterized protein Dmel_CG12746, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730949.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGV3, Q8IPQ4
      Related
      FBpp0078338
      Conserved Domains (1) summary
      cd03390
      Location:104 → 302
      PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

    3. NM_141294.5 → NP_649551.4  uncharacterized protein Dmel_CG12746, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649551.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGV3, Q8IPQ4
      Conserved Domains (1) summary
      cd03390
      Location:104 → 302
      PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGV3 Q8IGV3
    Q8T0D6 Q8T0D6

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