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    Ance Angiotensin converting enzyme [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34805, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Anceprovided by FlyBase
    Official Full Name
    Angiotensin converting enzymeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0012037
    Locus tag
    Dmel_CG8827
    See related
    AllianceGenome:FB:FBgn0012037
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ACE; ance; AnCE; ANCE; anon-EST:fe3D10; BG:DS08220.3; CG8827; Dmel\CG8827; race; Race; RACE
    Summary
    Enables metallopeptidase activity and peptidyl-dipeptidase activity. Involved in several processes, including metamorphosis; peptide hormone processing; and response to symbiotic bacterium. Located in extracellular space. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; epidermis; gut section; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ance in Genome Data Viewer
    Location:
    34E2-34E2; 2-50 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13905645..13909212)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13905645..13909212)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Centaurin gamma 1A Neighboring gene long non-coding RNA:CR44848 Neighboring gene Smg5 nonsense mediated mRNA decay factor Neighboring gene Ance-2 Neighboring gene Acylphosphatase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila melanogaster angiotensin I-converting enzyme expressed in Pichia pastoris resembles the C domain of the mammalian homologue and does not require glycosylation for secretion and enzymic activity. Williams TA, et al. Biochem J, 1996 Aug 15. PMID 8761461, Free PMC Article
    2. Characterisation of putative Drosophila angiotensin converting enzyme cDNA clones. Cornell MJ, et al. Biochem Soc Trans, 1993 Aug. PMID 8224398
    3. Inactivation of a tachykinin-related peptide: identification of four neuropeptide-degrading enzymes in neuronal membranes of insects from four different orders. Isaac RE, et al. Peptides, 2002 Apr. PMID 11897392
    4. Cloning and expression of an evolutionary conserved single-domain angiotensin converting enzyme from Drosophila melanogaster. Cornell MJ, et al. J Biol Chem, 1995 Jun 9. PMID 7775412
    5. Crystal structure of Drosophila angiotensin I-converting enzyme bound to captopril and lisinopril. Kim HM, et al. FEBS Lett, 2003 Mar 13. PMID 12633854

    See all (162) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data report the crystal structures of human testis ACE (tACE) and a homologue of ACE, known as AnCE, from Drosophila melanogaster in complex with a selenium analogue of captopril.
      Title: Structural characterization of angiotensin I-converting enzyme in complex with a selenium analogue of captopril.
    2. ANCE, which shares many enzymatic properties with mammalian ACE, is also a product of the male accessory gland of D. melanogaster.
      Title: Male accessory glands of Drosophila melanogaster make a secreted angiotensin I-converting enzyme (ANCE), suggesting a role for the peptide-processing enzyme in seminal fluid.
    3. Ance is required for spermatid differentiation.
      Title: The drosophila angiotensin-converting enzyme homologue Ance is required for spermiogenesis.
    4. ance may be required for the processing of a developmental peptide hormone or may function in concert with other peptidases to provide amino acids for the synthesis of adult proteins
      Title: Ance, a Drosophila angiotensin-converting enzyme homologue, is expressed in imaginal cells during metamorphosis and is regulated by the steroid, 20-hydroxyecdysone.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-dipeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in metamorphosis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in peptide hormone processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to symbiotic bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in sexual reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    angiotensin converting enzyme
    Names
    Ance-PA
    Ance-PB
    Ance-PC
    CG8827-PA
    CG8827-PB
    CG8827-PC
    angiotensin I-converting enzyme
    angiotensin-converting enzyme
    anon-fast-evolving-3D10
    race
    related to angiotensin converting enzyme
    NP_001285915.1
    NP_477046.1
    NP_723852.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13905645..13909212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057698.5 → NP_477046.1  angiotensin converting enzyme, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477046.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0P3, Q10714, Q27572, Q9NKE4, Q9TX66, Q9VJV3
      UniProtKB/TrEMBL
      X2J8C3
      Related
      FBpp0080129
      Conserved Domains (1) summary
      pfam01401
      Location:19 → 606
      Peptidase_M2; Angiotensin-converting enzyme

    2. NM_001298986.1 → NP_001285915.1  angiotensin converting enzyme, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285915.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0P3, Q10714, Q27572, Q9NKE4, Q9TX66, Q9VJV3
      UniProtKB/TrEMBL
      X2J8C3
      Conserved Domains (1) summary
      pfam01401
      Location:19 → 606
      Peptidase_M2; Angiotensin-converting enzyme

    3. NM_165070.3 → NP_723852.1  angiotensin converting enzyme, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723852.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0P3, Q10714, Q27572, Q9NKE4, Q9TX66, Q9VJV3
      UniProtKB/TrEMBL
      X2J8C3
      Related
      FBpp0080130
      Conserved Domains (1) summary
      pfam01401
      Location:19 → 606
      Peptidase_M2; Angiotensin-converting enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10714.3 Q10714
    X2J8C3 X2J8C3

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