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    mars mars [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36498, updated on 9-Dec-2024

    Summary

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    Official Symbol
    marsprovided by FlyBase
    Official Full Name
    marsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033845
    Locus tag
    Dmel_CG17064
    See related
    AllianceGenome:FB:FBgn0033845
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17064; d-hurp; D-HURP; dhrp/gkap; Dmel\CG17064; gkap; HURP; Mars
    Summary
    Enables microtubule binding activity and protein phosphatase 1 binding activity. Involved in several processes, including centrosome localization; kinetochore assembly; and mitotic spindle organization. Located in cytoplasm; nucleoplasm; and spindle. Colocalizes with kinetochore microtubule. Is expressed in several structures, including germline cell; gonad; head epidermis primordium; mesoderm; and neurogenic region. Orthologous to human DLGAP5 (DLG associated protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mars in Genome Data Viewer
    Location:
    50A13-50A14; 2-68 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13500621..13506011)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9388126..9393516)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene centromere identifier Neighboring gene bb in a boxcar Neighboring gene downstream of receptor kinase Neighboring gene Myb-interacting protein 120 Neighboring gene mitochondrial translation elongation factor Tu 1 Neighboring gene Vesicular monoamine transporter Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and expression of mars, a novel member of the guanylate kinase associated protein family in Drosophila. Bennett D, et al. Gene Expr Patterns, 2004 Sep. PMID 15261830
    2. The Drosophila microtubule-associated protein mars stabilizes mitotic spindles by crosslinking microtubules through its N-terminal region. Zhang G, et al. PLoS One, 2013. PMID 23593258, Free PMC Article
    3. Using Drosophila eye as a model system to characterize the function of mars gene in cell-cycle regulation. Yang CP, et al. Exp Cell Res, 2005 Jul 1. PMID 15922738
    4. mars and tousled-like kinase act in parallel to ensure chromosome fidelity in Drosophila. Li HH, et al. J Biomed Sci, 2009 Jun 1. PMID 19486529, Free PMC Article
    5. Drosophila mars is required for organizing kinetochore microtubules during mitosis. Yang CP, et al. Exp Cell Res, 2008 Oct 15. PMID 18761010

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mars and tlk function in parallel and a balance between mars activity and tlk activity is required for cells to progress through mitosis correctly, thus ensuring chromosome fidelity
      Title: mars and tousled-like kinase act in parallel to ensure chromosome fidelity in Drosophila.
    2. Mars is an important linker between the spindle and the centrosomes that is required for proper spindle organization during the rapid mitotic cycles in early embryogenesis.
      Title: Mars, a Drosophila protein related to vertebrate HURP, is required for the attachment of centrosomes to the mitotic spindle during syncytial nuclear divisions.
    3. results show that Mars is mainly localized on the kinetochore microtubules during mitosis; study provided further evidence showing that Mars is required for the assembly of kinetochore microtubules
      Title: Drosophila mars is required for organizing kinetochore microtubules during mitosis.
    4. Mars mediates spatially controlled dephosphorylation of dTACC, which is critical for spindle stabilization.
      Title: Mars promotes dTACC dephosphorylation on mitotic spindles to ensure spindle stability.
    5. The Drosophila eye was used as a model system to characterize the function of the mars gene in cell-cycle regulation.
      Title: Using Drosophila eye as a model system to characterize the function of mars gene in cell-cycle regulation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase 1 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in centrosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centrosome localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome segregation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in kinetochore assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in kinetochore assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spindle organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with kinetochore microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in spindle pole centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mars
    Names
    CG17064-PA
    CG17064-PB
    CG17064-PC
    CG17064-PD
    mars-PA
    mars-PB
    mars-PC
    mars-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13500621..13506011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299459.1 → NP_001286388.1  mars, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286388.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K3L1
      UniProtKB/TrEMBL
      E1JH57
      Conserved Domains (1) summary
      pfam03359
      Location:558 → 703
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    2. NM_001299458.1 → NP_001286387.1  mars, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286387.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K3L1
      UniProtKB/TrEMBL
      E1JH57
      Conserved Domains (1) summary
      pfam03359
      Location:558 → 703
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    3. NM_001169671.2 → NP_001163142.1  mars, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163142.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K3L1
      UniProtKB/TrEMBL
      E1JH57
      Conserved Domains (1) summary
      pfam03359
      Location:558 → 703
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    4. NM_137034.4 → NP_610878.1  mars, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610878.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K3L1
      UniProtKB/TrEMBL
      E1JH57
      Related
      FBpp0086788
      Conserved Domains (1) summary
      pfam03359
      Location:558 → 703
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JH57 E1JH57
    Q7K3L1.1 Q7K3L1

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