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    Rbsn-5 Rabenosyn-5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34110, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbsn-5provided by FlyBase
    Official Full Name
    Rabenosyn-5provided by FlyBase
    Primary source
    FLYBASE:FBgn0261064
    Locus tag
    Dmel_CG8506
    See related
    AllianceGenome:FB:FBgn0261064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8506; Dmel\CG8506; EEA1; MENE (2L)-C; MENE(2L)-C; rbsn; Rbsn; rbsn-5; Rbsn5
    Summary
    Enables small GTPase binding activity. Involved in several processes, including endosomal vesicle fusion; establishment of imaginal disc-derived wing hair orientation; and oocyte axis specification. Located in early endosome. Is expressed in adult head; embryonic/larval garland cell; organism; and spermatozoon. Orthologous to human RBSN (rabenosyn, RAB effector). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rbsn-5 in Genome Data Viewer
    Location:
    28E9-28E9; 2-30 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8159832..8161800)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8159832..8161800)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Phosphatidic Acid Phospholipase A1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Acyl-CoA binding protein 1 Neighboring gene piezo Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oskar-induced endocytic activation and actin remodeling for anchorage of the Drosophila germ plasm. Tanaka T, et al. Bioarchitecture, 2011 May. PMID 21922042, Free PMC Article
    2. Functional analysis of host factors that mediate the intracellular lifestyle of Cryptococcus neoformans. Qin QM, et al. PLoS Pathog, 2011 Jun. PMID 21698225, Free PMC Article
    3. Rab11 facilitates cross-talk between autophagy and endosomal pathway through regulation of Hook localization. Szatmári Z, et al. Mol Biol Cell, 2014 Feb. PMID 24356450, Free PMC Article
    4. Vps34 deficiency reveals the importance of endocytosis for podocyte homeostasis. Bechtel W, et al. J Am Soc Nephrol, 2013 Apr. PMID 23492732, Free PMC Article
    5. Endophilin B is required for the Drosophila oocyte to endocytose yolk downstream of Oskar. Tsai YC, et al. Development, 2014 Feb. PMID 24401369

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PI3K (III) differentially regulates localization of proteins at distinct membrane domains and Rbsn-5 mediates only a part of the PI3K (III)-dependent processes
      Title: Membrane protein location-dependent regulation by PI3K (III) and rabenosyn-5 in Drosophila wing cells.
    2. the Rbsn-Vps45 complex on early endosomes links Rab5 to the SNARE fusion machinery
      Title: Regulation of early endosomal entry by the Drosophila tumor suppressors Rabenosyn and Vps45.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosomal vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of imaginal disc-derived wing hair orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte microtubule cytoskeleton polarization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasma membrane to endosome transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pole plasm oskar mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rabenosyn-5
    Names
    CG8506-PA
    Rabenosyn5
    Rbsn-5-PA
    dRabenosyn
    early endosomal antigen 1
    rabenosyn

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8159832..8161800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135342.5 → NP_609186.1  Rabenosyn-5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609186.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLS5
      Related
      FBpp0079203
      Conserved Domains (2) summary
      cd15716
      Location:174 → 259
      FYVE_RBNS5; FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins
      pfam11464
      Location:449 → 487
      Rbsn; Rabenosyn Rab binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLS5 Q9VLS5

    Gene LinkOut

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