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    Hsp110 Heat shock protein 110 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39557, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hsp110provided by FlyBase
    Official Full Name
    Heat shock protein 110provided by FlyBase
    Primary source
    FLYBASE:FBgn0026418
    Locus tag
    Dmel_CG6603
    See related
    AllianceGenome:FB:FBgn0026418
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0041/12; 0318/20; 1342/17; 1348/02; 1485/13; anon-WO0118547.302; BEST:LD32772; CG6603; dHsp110; Dmel\CG6603; HSC-70; HSC-70cb; Hsc70; HSC70; hsc70cb; hsc70Cb; Hsc70cb; Hsc70Cb; Hsc70CB; HSC70cb; HSP110; HSP110-1; l(3)00082; l(3)07621; l(3)134217; l(3)148513; l(3)70Ca; l(3)70Cb; l(3)S134217; l(3)S134802; l(3)S148513; LD32772
    Summary
    Predicted to enable adenyl-nucleotide exchange factor activity and denatured protein binding activity. Predicted to be involved in cellular response to heat; chaperone-mediated protein complex assembly; and protein folding. Located in cytosol and nucleus. Is expressed in several structures, including adult brain cell body rind; adult head; ganglia; gut section; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to several human genes including HSPA4 (heat shock protein family A (Hsp70) member 4) and HSPH1 (heat shock protein family H (Hsp110) member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hsp110 in Genome Data Viewer
    Location:
    70C15-70C15; 3-41 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14037019..14043686)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14030119..14036786)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene endosulfine Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR42871 Neighboring gene uncharacterized protein Neighboring gene Neuralized E3 ubiquitin protein ligase 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppression of aggregate and amyloid formation by a novel intrinsically disordered region in metazoan Hsp110 chaperones. Yakubu UM, et al. J Biol Chem, 2021 Jan-Jun. PMID 33753171, Free PMC Article
    2. Clearance of variant Creutzfeldt-Jakob disease prions in vivo by the Hsp70 disaggregase system. Thackray AM, et al. Brain, 2022 Sep 14. PMID 35446941, Free PMC Article
    3. The hsp110 and Grp1 70 stress proteins: newly recognized relatives of the Hsp70s. Easton DP, et al. Cell Stress Chaperones, 2000 Oct. PMID 11048651, Free PMC Article
    4. Studying polyglutamine diseases in Drosophila. Xu Z, et al. Exp Neurol, 2015 Dec. PMID 26257024, Free PMC Article
    5. Integrating protein-protein interaction networks with phenotypes reveals signs of interactions. Vinayagam A, et al. Nat Methods, 2014 Jan. PMID 24240319, Free PMC Article

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HSP40 and HSP110 function together in protein homeostasis control.
      Title: Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables denatured protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in chaperone-mediated protein complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    heat shock protein 110
    Names
    CG6603-PA
    CG6603-PB
    CG6603-PC
    CG6603-PE
    CG6603-PF
    CG6603-PG
    CG6603-PH
    CG6603-PI
    Hsc70Cb
    Hsp110-PA
    Hsp110-PB
    Hsp110-PC
    Hsp110-PE
    Hsp110-PF
    Hsp110-PG
    Hsp110-PH
    Hsp110-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14037019..14043686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274893.1 → NP_001261822.1  heat shock protein 110, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261822.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUC1, Q9XZT5
      Conserved Domains (2) summary
      cd10228
      Location:2 → 381
      HSPA4_like_NDB; Nucleotide-binding domain of 105/110 kDa heat shock proteins including HSPA4 and similar proteins
      pfam00012
      Location:3 → 650
      HSP70; Hsp70 protein

    2. NM_001202174.2 → NP_001189103.1  heat shock protein 110, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189103.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSL3, Q9XZT5
      Conserved Domains (2) summary
      cd10228
      Location:2 → 381
      HSPA4_like_NDB; Nucleotide-binding domain of 105/110 kDa heat shock proteins including HSPA4 and similar proteins
      pfam00012
      Location:3 → 682
      HSP70; Hsp70 protein

    3. NM_140430.4 → NP_648687.1  heat shock protein 110, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648687.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUC1, Q9XZT5
      Related
      FBpp0075513
      Conserved Domains (2) summary
      cd10228
      Location:2 → 381
      HSPA4_like_NDB; Nucleotide-binding domain of 105/110 kDa heat shock proteins including HSPA4 and similar proteins
      pfam00012
      Location:3 → 650
      HSP70; Hsp70 protein

    4. NM_001202172.2 → NP_001189101.1  heat shock protein 110, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189101.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUC1, Q9XZT5
      Conserved Domains (2) summary
      cd10228
      Location:2 → 381
      HSPA4_like_NDB; Nucleotide-binding domain of 105/110 kDa heat shock proteins including HSPA4 and similar proteins
      pfam00012
      Location:3 → 650
      HSP70; Hsp70 protein

    5. NM_001202175.2 → NP_001189104.1  heat shock protein 110, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189104.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSL3, Q9XZT5
      Conserved Domains (2) summary
      cd10228
      Location:2 → 381
      HSPA4_like_NDB; Nucleotide-binding domain of 105/110 kDa heat shock proteins including HSPA4 and similar proteins
      pfam00012
      Location:3 → 682
      HSP70; Hsp70 protein

    6. NM_168573.3 → NP_729951.1  heat shock protein 110, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729951.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUC1, Q9XZT5
      Related
      FBpp0075514
      Conserved Domains (2) summary
      cd10228
      Location:2 → 381
      HSPA4_like_NDB; Nucleotide-binding domain of 105/110 kDa heat shock proteins including HSPA4 and similar proteins
      pfam00012
      Location:3 → 650
      HSP70; Hsp70 protein

    7. NM_001202173.2 → NP_001189102.1  heat shock protein 110, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189102.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUC1, Q9XZT5
      Conserved Domains (2) summary
      cd10228
      Location:2 → 381
      HSPA4_like_NDB; Nucleotide-binding domain of 105/110 kDa heat shock proteins including HSPA4 and similar proteins
      pfam00012
      Location:3 → 650
      HSP70; Hsp70 protein

    8. NM_168574.1 → NP_729952.1  heat shock protein 110, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729952.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUC1, Q9XZT5
      Related
      FBpp0075515, FBtr0075773
      Conserved Domains (2) summary
      cd10228
      Location:2 → 381
      HSPA4_like_NDB; Nucleotide-binding domain of 105/110 kDa heat shock proteins including HSPA4 and similar proteins
      pfam00012
      Location:3 → 650
      HSP70; Hsp70 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MSL3 M9MSL3
    O96818 O96818
    Q9VUC1 Q9VUC1
    Q9XZT5 Q9XZT5

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