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    RluA-2 RluA pseudouridine synthase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34440, updated on 9-Dec-2024

    Summary

    Official Symbol
    RluA-2provided by FlyBase
    Official Full Name
    RluA pseudouridine synthase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0032256
    Locus tag
    Dmel_CG6187
    See related
    AllianceGenome:FB:FBgn0032256
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6187; Dmel\CG6187; yumo
    Summary
    Enables pseudouridine synthase activity. Involved in mRNA pseudouridine synthesis. Is expressed in larval dorsal multidendritic neurons and organism. Orthologous to human RPUSD2 (RNA pseudouridine synthase domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See RluA-2 in Genome Data Viewer
    Location:
    31F1-31F1; 2-43 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10477073..10482975)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10477073..10482975)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Lysosomal alpha-mannosidase II Neighboring gene RluA pseudouridine synthase 1 Neighboring gene Grip75 Neighboring gene Component of oligomeric golgi complex 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    RluA pseudouridine synthase 2
    Names
    CG6187-PA
    CG6187-PC
    CG6187-PD
    CG6187-PE
    RluA-2-PA
    RluA-2-PC
    RluA-2-PD
    RluA-2-PE

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10477073..10482975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135567.4NP_609411.1  RluA pseudouridine synthase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609411.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TM3, Q9VKU8
      Related
      FBpp0079622
      Conserved Domains (2) summary
      cd02557
      Location:202386
      PseudoU_synth_ScRIB2; Pseudouridine synthases similar to Saccharomyces cerevisiae RIB2
      cd00165
      Location:157229
      S4; S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized ...
    2. NM_001201854.2NP_001188783.1  RluA pseudouridine synthase 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188783.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRH0
      Conserved Domains (2) summary
      cd02557
      Location:202386
      PseudoU_synth_ScRIB2; Pseudouridine synthases similar to Saccharomyces cerevisiae RIB2
      cd00165
      Location:157229
      S4; S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized ...
    3. NM_001273423.1NP_001260352.1  RluA pseudouridine synthase 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260352.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFI9
      Conserved Domains (1) summary
      TIGR00005
      Location:150210
      rluA_subfam; pseudouridine synthase, RluA family
    4. NM_001201853.2NP_001188782.2  RluA pseudouridine synthase 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188782.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TM3, Q9VKU8
      Conserved Domains (2) summary
      cd02557
      Location:202386
      PseudoU_synth_ScRIB2; Pseudouridine synthases similar to Saccharomyces cerevisiae RIB2
      cd00165
      Location:157229
      S4; S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized ...