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    Shark SH2 ankyrin repeat kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44353, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sharkprovided by FlyBase
    Official Full Name
    SH2 ankyrin repeat kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015295
    Locus tag
    Dmel_CG18247
    See related
    AllianceGenome:FB:FBgn0015295
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18247; Dmel\CG18247; dShark; dtk7; Dtk7; l(2)W4; l(2R)W4; shark; SHARK; Syk; SYK/SHARK; Tk7
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Involved in several processes, including dorsal appendage formation; dorsal closure, elongation of leading edge cells; and maintenance of epithelial cell apical/basal polarity. Located in cell cortex. Is expressed in several structures, including ectoderm; embryonic/larval salivary gland; epithelium; germline cell; and gut section. Human ortholog(s) of this gene implicated in immunodeficiency 48 and severe combined immunodeficiency. Orthologous to human ZAP70 (zeta chain of T cell receptor associated protein kinase 70). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Shark in Genome Data Viewer
    Location:
    52F8-52F8; 2-78 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16199426..16202884, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12086931..12090389, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Lipoyltransferase 1 Neighboring gene transfer RNA:Glutamine-CTG 1-1 Neighboring gene mrj Neighboring gene transfer RNA:Glutamic acid-TTC 1-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Shark, a Src homology 2, ankyrin repeat, tyrosine kinase, is expressed on the apical surfaces of ectodermal epithelia. Ferrante AW Jr, et al. Proc Natl Acad Sci U S A, 1995 Mar 14. PMID 7892198, Free PMC Article
    2. Draper/CED-1 mediates an ancient damage response to control inflammatory blood cell migration in vivo. Evans IR, et al. Curr Biol, 2015 Jun 15. PMID 26028435, Free PMC Article
    3. Cytoskeletal Exposure in the Regulation of Immunity and Initiation of Tissue Repair. Gordon O, et al. Bioessays, 2019 Jul. PMID 31157930
    4. α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster. Gordon O, et al. Elife, 2018 Sep 27. PMID 30260317, Free PMC Article
    5. Natural history and functional divergence of protein tyrosine kinases. Gu J, et al. Gene, 2003 Oct 23. PMID 14604791

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Draper-Src42A-Shark interactions are strikingly similar to mammalian immunoreceptor-SFK-Syk signalling events in mammalian myeloid and lymphoid cells.
      Title: Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling.
    2. Required in follicle cells for cell migration and chorion deposition.
      Title: bullwinkle and shark regulate dorsal-appendage morphogenesis in Drosophila oogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal appendage formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dorsal appendage formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in dorsal closure, elongation of leading edge cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg chorion assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of epithelial cell apical/basal polarity IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SH2 ankyrin repeat kinase
    Names
    CG18247-PA
    Shark-PA
    Src homology 2 ankyrin repeat tyrosine kinase
    Src homology 2, ankyrin repeat, tyrosine kinase
    Src homology2, ankyrin repeat, tyrosine kinase
    tyrosine kinase 7
    NP_524743.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16199426..16202884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080004.4 → NP_524743.2  SH2 ankyrin repeat kinase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524743.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24145, Q26299, Q9V7K5
      Related
      FBpp0086382
      Conserved Domains (8) summary
      smart00219
      Location:662 → 921
      TyrKc; Tyrosine kinase, catalytic domain
      cd10347
      Location:8 → 91
      SH2_Nterm_shark_like; N-terminal Src homology 2 (SH2) domain found in SH2 domains, ANK, and kinase domain (shark) proteins
      cd10348
      Location:287 → 395
      SH2_Cterm_shark_like; C-terminal Src homology 2 (SH2) domain found in SH2 domains, ANK, and kinase domain (shark) proteins
      cd00204
      Location:117 → 241
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd05060
      Location:666 → 926
      PTKc_Syk_like; Catalytic domain of Spleen Tyrosine Kinase-like Protein Tyrosine Kinases
      pfam12796
      Location:158 → 247
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:224 → 274
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:153 → 184
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24145.2 Q24145

    Gene LinkOut

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