Adgrl1 adhesion G protein-coupled receptor L1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adgrl1provided by RGD
Official Full Name: adhesion G protein-coupled receptor L1provided by RGD
Primary source: RGD:620768
See related: EnsemblRapid:ENSRNOG00000029134 AllianceGenome:RGD:620768
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CL1BA; Lphn1
Summary: Enables cell adhesion molecule binding activity; toxic substance binding activity; and transmembrane signaling receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within positive regulation of synapse assembly. Located in growth cone; plasma membrane; and synapse. Is active in glutamatergic synapse and presynaptic membrane. Orthologous to human ADGRL1 (adhesion G protein-coupled receptor L1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 198.5), Kidney (RPKM 133.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (41107162..41148752, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (24202405..24244137, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (25029037..25069146)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination.
Title: Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination.
Neurexin 1 binding to latrophilin-1 produces a stable intercellular adhesion complex.
Title: High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex.
Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities.
Title: Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities.
further cleavage of CIRL by a second protease results in a soluble form of CIRL
Title: Dissociation of the subunits of the calcium-independent receptor of alpha-latrotoxin as a result of two-step proteolysis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables cell adhesion molecule binding	IDA Inferred from Direct Assay more info	PubMed
enables latrotoxin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables latrotoxin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables toxic substance binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adhesion G protein-coupled receptor L1

Names: CIRL-1; calcium-independent alpha-latrotoxin receptor 1; latrophilin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431366.1 → NP_001418295.1 adhesion G protein-coupled receptor L1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A8I6AG63, A6IYC5
NM_022962.2 → NP_075251.1 adhesion G protein-coupled receptor L1 isoform 1 precursor

See identical proteins and their annotated locations for NP_075251.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A8I6AG63

Related

ENSRNOP00000043269.4, ENSRNOT00000045699.6

Conserved Domains (7) summary

smart00303
Location:797 → 849

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:476 → 539

HormR; Domain present in hormone receptors

pfam00002
Location:857 → 1092

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02140
Location:48 → 128

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1112 → 1471

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:550 → 771

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02549
Location:142 → 398

OLF; Olfactomedin-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

41107162..41148752 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097967.2 → XP_038953895.1 adhesion G protein-coupled receptor L1 isoform X4

Conserved Domains (8) summary

smart00303
Location:792 → 844

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:471 → 534

HormR; Domain present in hormone receptors

PHA03247
Location:393 → 477

PHA03247; large tegument protein UL36; Provisional

cd16007
Location:851 → 1108

7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02140
Location:48 → 128

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1107 → 1466

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:544 → 768

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02549
Location:137 → 393

OLF; Olfactomedin-like domain
XM_039097965.2 → XP_038953893.1 adhesion G protein-coupled receptor L1 isoform X2

Conserved Domains (8) summary

smart00303
Location:792 → 844

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:471 → 534

HormR; Domain present in hormone receptors

PHA03247
Location:393 → 477

PHA03247; large tegument protein UL36; Provisional

cd16007
Location:851 → 1108

7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02140
Location:48 → 128

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1107 → 1511

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:544 → 768

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02549
Location:137 → 393

OLF; Olfactomedin-like domain
XM_039097964.2 → XP_038953892.1 adhesion G protein-coupled receptor L1 isoform X1

Related

ENSRNOP00000086387.2, ENSRNOT00000103294.2

Conserved Domains (8) summary

smart00303
Location:797 → 849

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:476 → 539

HormR; Domain present in hormone receptors

PHA03247
Location:398 → 482

PHA03247; large tegument protein UL36; Provisional

cd16007
Location:856 → 1113

7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02140
Location:48 → 128

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1112 → 1516

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:549 → 773

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02549
Location:142 → 398

OLF; Olfactomedin-like domain
XM_039097966.2 → XP_038953894.1 adhesion G protein-coupled receptor L1 isoform X3

UniProtKB/TrEMBL

A0A8I6AG63

Conserved Domains (8) summary

smart00303
Location:798 → 850

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:477 → 540

HormR; Domain present in hormone receptors

PHA03247
Location:399 → 483

PHA03247; large tegument protein UL36; Provisional

cd16007
Location:857 → 1114

7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02140
Location:48 → 128

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1113 → 1472

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:550 → 774

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02549
Location:143 → 399

OLF; Olfactomedin-like domain
XM_039097969.2 → XP_038953897.1 adhesion G protein-coupled receptor L1 isoform X6

UniProtKB/TrEMBL

A0A8I6G3M0

Related

ENSRNOP00000091684.2, ENSRNOT00000098082.2

Conserved Domains (7) summary

smart00303
Location:694 → 746

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:373 → 436

HormR; Domain present in hormone receptors

PHA03247
Location:295 → 379

PHA03247; large tegument protein UL36; Provisional

cd16007
Location:753 → 1010

7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02354
Location:1009 → 1368

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:446 → 670

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02549
Location:39 → 295

OLF; Olfactomedin-like domain
XM_039097968.2 → XP_038953896.1 adhesion G protein-coupled receptor L1 isoform X5

UniProtKB/TrEMBL

A0A8I6G3M0

Conserved Domains (7) summary

smart00303
Location:699 → 751

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:378 → 441

HormR; Domain present in hormone receptors

PHA03247
Location:300 → 384

PHA03247; large tegument protein UL36; Provisional

cd16007
Location:758 → 1015

7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02354
Location:1014 → 1373

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:451 → 675

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02549
Location:44 → 300

OLF; Olfactomedin-like domain
XM_039097971.2 → XP_038953899.1 adhesion G protein-coupled receptor L1 isoform X7

UniProtKB/TrEMBL

A0A8I6AB35, A0A8I6G3M0, A6IYC7

Related

ENSRNOP00000079689.2, ENSRNOT00000115789.2

Conserved Domains (7) summary

smart00303
Location:621 → 673

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:300 → 363

HormR; Domain present in hormone receptors

PHA03247
Location:222 → 306

PHA03247; large tegument protein UL36; Provisional

cd16007
Location:680 → 937

7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02354
Location:936 → 1295

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:373 → 597

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02549
Location:1 → 222

OLF; Olfactomedin-like domain
XM_063278273.1 → XP_063134343.1 adhesion G protein-coupled receptor L1 isoform X7

UniProtKB/TrEMBL

A0A8I6AB35, A0A8I6G3M0, A6IYC7