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Ntrk2 neurotrophic receptor tyrosine kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25054, updated on 9-Dec-2024

Summary

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Official Symbol: Ntrk2provided by RGD
Official Full Name: neurotrophic receptor tyrosine kinase 2provided by RGD
Primary source: RGD:3213
See related: EnsemblRapid:ENSRNOG00000018839 AllianceGenome:RGD:3213
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tkrb; trkB; TRKB1; trk-B; RATTRKB1
Summary: Enables several functions, including brain-derived neurotrophic factor binding activity; brain-derived neurotrophic factor receptor activity; and protein homodimerization activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; positive regulation of cell communication; and regulation of neuron projection development. Acts upstream of or within positive regulation of glucocorticoid receptor signaling pathway. Located in several cellular components, including dendritic spine; distal axon; and perikaryon. Is active in glutamatergic synapse; postsynaptic membrane; and presynapse. Used to study glaucoma. Biomarker of several diseases, including alcohol use disorder; anxiety disorder (multiple); attention deficit hyperactivity disorder; borna disease; and depressive disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 177.9), Spleen (RPKM 47.3) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Ntrk2 in Genome Data Viewer

Location:: 17p14

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (5560558..5875899, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (5558992..5870299, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (5934651..6245778, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Inflammation/NF-kappaB and BDNF/TrkB/CREB Pathways in the Cerebellum Are Implicated in the Changes in Spatial Working Memory After Both Morphine Dependence and Withdrawal in Rat.
Title: The Inflammation/NF-κB and BDNF/TrkB/CREB Pathways in the Cerebellum Are Implicated in the Changes in Spatial Working Memory After Both Morphine Dependence and Withdrawal in Rat.
Stem cells alleviate OGD/R mediated stress response in PC12 cells following a co-culture: modulation of the apoptotic cascade through BDNF-TrkB signaling.
Title: Stem cells alleviate OGD/R mediated stress response in PC12 cells following a co-culture: modulation of the apoptotic cascade through BDNF-TrkB signaling.
Inhibition of mGluR5 alters BDNF/TrkB and GLT-1 expression in the prefrontal cortex and hippocampus and ameliorates PTSD-like behavior in rats.
Title: Inhibition of mGluR5 alters BDNF/TrkB and GLT-1 expression in the prefrontal cortex and hippocampus and ameliorates PTSD-like behavior in rats.
DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons.
Title: DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons.
Effects of Tail Pinch on BDNF and trkB Expression in the Hippocampus of Roman Low- (RLA) and High-Avoidance (RHA) Rats.
Title: Effects of Tail Pinch on BDNF and trkB Expression in the Hippocampus of Roman Low- (RLA) and High-Avoidance (RHA) Rats.
Chemogenetic inhibition of TrkB signalling reduces phrenic motor neuron survival and size.
Title: Chemogenetic inhibition of TrkB signalling reduces phrenic motor neuron survival and size.
Acute intrahippocampal administration of melanin-concentrating hormone impairs memory consolidation and decreases the expression of MCHR-1 and TrkB receptors.
Title: Acute intrahippocampal administration of melanin-concentrating hormone impairs memory consolidation and decreases the expression of MCHR-1 and TrkB receptors.
Acute Stress Induces Different Changes on the Expression of BDNF and trkB in the Mesocorticolimbic System of Two Lines of Rats Differing in Their Response to Stressors.
Title: Acute Stress Induces Different Changes on the Expression of BDNF and trkB in the Mesocorticolimbic System of Two Lines of Rats Differing in Their Response to Stressors.
Trifluoro-icaritin ameliorates spared nerve injury-induced neuropathic pain by inhibiting microglial activation through alpha7nAChR-mediated blockade of BDNF/TrkB/KCC2 signaling in the spinal cord of rats.
Title: Trifluoro-icaritin ameliorates spared nerve injury-induced neuropathic pain by inhibiting microglial activation through α7nAChR-mediated blockade of BDNF/TrkB/KCC2 signaling in the spinal cord of rats.
Enhanced BDNF and TrkB Activation Enhance GABA Neurotransmission in Cerebellum in Hyperammonemia.
Title: Enhanced BDNF and TrkB Activation Enhance GABA Neurotransmission in Cerebellum in Hyperammonemia.

Submit: New GeneRIF Correction See all GeneRIFs (204)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138872 (e-PCR)
- UniSTS:220959

RH133106 (e-PCR)
- UniSTS:216389

Ntrk2 (e-PCR), detects polymorphism
- UniSTS:260424

D17Wox10 (e-PCR)
- UniSTS:118121

RH138199 (e-PCR)
- UniSTS:220286

BF388200 (e-PCR)
- UniSTS:244868

RH139520 (e-PCR)
- UniSTS:221606

D17Got7 (e-PCR)
- UniSTS:111787

BF386266 (e-PCR)
- UniSTS:243648

BF390725 (e-PCR)
- UniSTS:249542

D17Arb15 (e-PCR)
- UniSTS:240073

Ntrk2 (e-PCR), detects polymorphism
- UniSTS:265674

BE097527 (e-PCR)
- UniSTS:244684

D17Rat4 (e-PCR)
- UniSTS:119513

RH129925 (e-PCR)
- UniSTS:213213

RH140355 (e-PCR)
- UniSTS:222431

RH135318 (e-PCR)
- UniSTS:218595

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables brain-derived neurotrophic factor binding	IDA Inferred from Direct Assay more info	PubMed
enables brain-derived neurotrophic factor binding	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables brain-derived neurotrophic factor binding	ISO Inferred from Sequence Orthology more info
enables brain-derived neurotrophic factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables brain-derived neurotrophic factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables neurotrophin binding	IDA Inferred from Direct Assay more info	PubMed
enables neurotrophin binding	ISO Inferred from Sequence Orthology more info
enables neurotrophin binding	ISS Inferred from Sequence or Structural Similarity more info
enables neurotrophin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neurotrophin receptor activity	IEA Inferred from Electronic Annotation more info
enables neurotrophin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain-derived neurotrophic factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein serine/threonine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to brain-derived neurotrophic factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to brain-derived neurotrophic factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to nerve growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in central nervous system neuron development	IEA Inferred from Electronic Annotation more info
involved_in central nervous system neuron development	ISO Inferred from Sequence Orthology more info
involved_in central nervous system neuron development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cerebral cortex development	IEA Inferred from Electronic Annotation more info
involved_in cerebral cortex development	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex development	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in circadian rhythm	IEA Inferred from Electronic Annotation more info
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in feeding behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in glutamate secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in learning	IEA Inferred from Electronic Annotation more info
involved_in learning	ISO Inferred from Sequence Orthology more info
involved_in learning	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-term memory	IDA Inferred from Direct Assay more info	PubMed
involved_in long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in mechanoreceptor differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mechanoreceptor differentiation	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in myelination in peripheral nervous system	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myelination in peripheral nervous system	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid-beta formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of anoikis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of anoikis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron migration	IEA Inferred from Electronic Annotation more info
involved_in neuron migration	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuronal action potential propagation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuronal action potential propagation	ISO Inferred from Sequence Orthology more info
involved_in neurotrophin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peripheral nervous system neuron development	IEA Inferred from Electronic Annotation more info
involved_in peripheral nervous system neuron development	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of glucocorticoid receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in response to auditory stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in retinal rod cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retinal rod cell development	ISO Inferred from Sequence Orthology more info
involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in trans-synaptic signaling by neuropeptide, modulating synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vasculogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasculogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	TAS Traceable Author Statement more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	IEA Inferred from Electronic Annotation more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: BDNF/NT-3 growth factors receptor

Names: GP145-TrkB/GP95-TrkB; neural receptor protein-tyrosine kinase (trkB); neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; trkB tyrosine kinase

NP_001156640.1

EC 2.7.10.1

NP_036863.1

EC 2.7.10.1

XP_006253569.1

EC 2.7.10.1

XP_008769647.1

EC 2.7.10.1

XP_008769648.1

EC 2.7.10.1

XP_008769649.1

EC 2.7.10.1

XP_017455945.1

EC 2.7.10.1

XP_038951298.1

EC 2.7.10.1

XP_063132139.1

EC 2.7.10.1

XP_063132140.1

EC 2.7.10.1

XP_063132141.1

EC 2.7.10.1

XP_063132142.1

EC 2.7.10.1

XP_063132143.1

EC 2.7.10.1

XP_063132144.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163168.3 → NP_001156640.1 BDNF/NT-3 growth factors receptor isoform 2 precursor

See identical proteins and their annotated locations for NP_001156640.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks multiple coding exons and uses a distinct terminal exon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to to isoform 1.

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I5ZVM2, A6KAJ1

Related

ENSRNOP00000070128.1, ENSRNOT00000090914.3

Conserved Domains (7) summary

smart00013
Location:31 → 64

LRRNT; Leucine rich repeat N-terminal domain

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
NM_012731.3 → NP_036863.1 BDNF/NT-3 growth factors receptor isoform 1 precursor

See identical proteins and their annotated locations for NP_036863.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

Q63604, Q63605, Q63606

Related

ENSRNOP00000045635.1, ENSRNOT00000042145.4

Conserved Domains (7) summary

cd05855
Location:301 → 379

Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB

smart00410
Location:204 → 283

IG_like; Immunoglobulin like

cd05093
Location:531 → 818

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

pfam07714
Location:537 → 806

Pkinase_Tyr; Protein tyrosine kinase

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

cl11960
Location:204 → 283

Ig; Immunoglobulin domain

cl15307
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

5560558..5875899 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063276070.1 → XP_063132140.1 BDNF/NT-3 growth factors receptor isoform X2

UniProtKB/Swiss-Prot

Q63604, Q63605, Q63606
XM_017600456.3 → XP_017455945.1 BDNF/NT-3 growth factors receptor isoform X1

UniProtKB/TrEMBL

A0A0G2K5X6

Conserved Domains (6) summary

cd05093
Location:547 → 834

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
XM_063276069.1 → XP_063132139.1 BDNF/NT-3 growth factors receptor isoform X2

UniProtKB/Swiss-Prot

Q63604, Q63605, Q63606
XM_008771426.4 → XP_008769648.1 BDNF/NT-3 growth factors receptor isoform X1

See identical proteins and their annotated locations for XP_008769648.1

UniProtKB/TrEMBL

A0A0G2K5X6

Conserved Domains (6) summary

cd05093
Location:547 → 834

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
XM_039095370.2 → XP_038951298.1 BDNF/NT-3 growth factors receptor isoform X1

UniProtKB/TrEMBL

A0A0G2K5X6

Conserved Domains (6) summary

cd05093
Location:547 → 834

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
XM_008771425.4 → XP_008769647.1 BDNF/NT-3 growth factors receptor isoform X1

See identical proteins and their annotated locations for XP_008769647.1

UniProtKB/TrEMBL

A0A0G2K5X6

Related

ENSRNOP00000073595.1, ENSRNOT00000082611.3

Conserved Domains (6) summary

cd05093
Location:547 → 834

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
XM_063276071.1 → XP_063132141.1 BDNF/NT-3 growth factors receptor isoform X3
XM_008771427.4 → XP_008769649.1 BDNF/NT-3 growth factors receptor isoform X5

UniProtKB/TrEMBL

A0A8I5ZVM2

Conserved Domains (7) summary

cd05855
Location:301 → 379

Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB

smart00013
Location:31 → 64

LRRNT; Leucine rich repeat N-terminal domain

smart00410
Location:204 → 283

IG_like; Immunoglobulin like

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

cl11960
Location:204 → 283

Ig; Immunoglobulin domain

cl15307
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
XM_006253507.5 → XP_006253569.1 BDNF/NT-3 growth factors receptor isoform X4

UniProtKB/TrEMBL

A0A8I5ZVM2

Conserved Domains (7) summary

cd05855
Location:301 → 379

Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB

smart00013
Location:31 → 64

LRRNT; Leucine rich repeat N-terminal domain

smart00410
Location:204 → 283

IG_like; Immunoglobulin like

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

cl11960
Location:204 → 283

Ig; Immunoglobulin domain

cl15307
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
XM_063276072.1 → XP_063132142.1 BDNF/NT-3 growth factors receptor isoform X6

UniProtKB/TrEMBL

A0A8I5ZVM2, A6KAJ1
XM_063276073.1 → XP_063132143.1 BDNF/NT-3 growth factors receptor isoform X6

UniProtKB/TrEMBL

A0A8I5ZVM2, A6KAJ1
XM_063276074.1 → XP_063132144.1 BDNF/NT-3 growth factors receptor isoform X6

UniProtKB/TrEMBL

A0A8I5ZVM2, A6KAJ1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001163169.1: Suppressed sequence

Description

NM_001163169.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.