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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_031675.2 → NP_113863.2 alpha-actinin-4
See identical proteins and their annotated locations for NP_113863.2
Status: VALIDATED
- Source sequence(s)
-
AI070095, BC061788, BQ206143, CB805703
- UniProtKB/Swiss-Prot
- Q6P786, Q9QXQ0
- UniProtKB/TrEMBL
- A0A8L2UKD4, A6J9M1
- Related
- ENSRNOP00000027773.7, ENSRNOT00000027773.9
- Conserved Domains (6) summary
-
- cd00014
Location:164 → 268
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
- cd00051
Location:769 → 836
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd00176
Location:414 → 640
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam00307
Location:51 → 149
- CH; Calponin homology (CH) domain
- pfam08726
Location:841 → 907
- EFhand_Ca_insen; Ca2+ insensitive EF hand
- pfam13499
Location:771 → 835
- EF-hand_7; EF-hand domain pair
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCr8
Genomic
-
NC_086019.1 Reference GRCr8
- Range
-
93310294..93379369 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_006228688.3 → XP_006228750.1 alpha-actinin-4 isoform X2
- UniProtKB/TrEMBL
- A0A0G2K013, A0A8L2UKD4
- Conserved Domains (6) summary
-
- cd00014
Location:164 → 268
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
- cd00051
Location:769 → 831
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd00176
Location:414 → 640
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam00307
Location:51 → 149
- CH; Calponin homology (CH) domain
- pfam08726
Location:836 → 902
- EFhand_Ca_insen; Ca2+ insensitive EF hand
- pfam13499
Location:771 → 830
- EF-hand_7; EF-hand domain pair
-
XM_006228689.3 → XP_006228751.1 alpha-actinin-4 isoform X3
- UniProtKB/TrEMBL
-
A0A8L2UKD4
- Related
- ENSRNOP00000100770.1, ENSRNOT00000140892.1
- Conserved Domains (6) summary
-
- cd00014
Location:164 → 268
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
- cd00051
Location:769 → 831
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd00176
Location:414 → 640
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam00307
Location:51 → 149
- CH; Calponin homology (CH) domain
- pfam08726
Location:836 → 902
- EFhand_Ca_insen; Ca2+ insensitive EF hand
- pfam13499
Location:771 → 830
- EF-hand_7; EF-hand domain pair
-
XM_006228687.3 → XP_006228749.1 alpha-actinin-4 isoform X1
- UniProtKB/TrEMBL
-
A0A8L2UKD4
- Related
- ENSRNOP00000106020.1, ENSRNOT00000136183.1
- Conserved Domains (6) summary
-
- cd00014
Location:164 → 268
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
- cd00051
Location:769 → 836
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd00176
Location:414 → 640
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam00307
Location:51 → 149
- CH; Calponin homology (CH) domain
- pfam08726
Location:841 → 907
- EFhand_Ca_insen; Ca2+ insensitive EF hand
- pfam13499
Location:771 → 835
- EF-hand_7; EF-hand domain pair
-
XM_008759185.3 → XP_008757407.1 alpha-actinin-4 isoform X4
- UniProtKB/TrEMBL
-
A0A8L2UKD4
- Related
- ENSRNOP00000103109.1, ENSRNOT00000151438.1
- Conserved Domains (5) summary
-
- cd00014
Location:164 → 268
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
- cd00051
Location:769 → 858
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd00176
Location:414 → 640
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam00307
Location:51 → 149
- CH; Calponin homology (CH) domain
- pfam08726
Location:863 → 929
- EFhand_Ca_insen; Ca2+ insensitive EF hand