Il1r1 interleukin 1 receptor type 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il1r1provided by RGD
Official Full Name: interleukin 1 receptor type 1provided by RGD
Primary source: RGD:2892
See related: EnsemblRapid:ENSRNOG00000014504 AllianceGenome:RGD:2892
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IL-1R-1; IL-1RT1; IL-1RT-1; IL-1R-alpha
Summary: Enables ionotropic glutamate receptor binding activity. Involved in several processes, including interleukin-1-mediated signaling pathway; positive regulation of neuron migration; and response to odorant. Located in axon; cell surface; and extracellular space. Part of protein-containing complex. Biomarker of pulpitis. Human ortholog(s) of this gene implicated in chronic recurrent multifocal osteomyelitis; systemic scleroderma; and type 1 diabetes mellitus. Orthologous to human IL1R1 (interleukin 1 receptor type 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 238.9), Lung (RPKM 115.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q22

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (50000558..50076579)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (42504917..42580958)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (46962291..47038139)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of IL1R1 or CASP4 attenuates spinal cord injury through ameliorating NLRP3 inflammasome-induced pyroptosis.
Title: Inhibition of IL1R1 or CASP4 attenuates spinal cord injury through ameliorating NLRP3 inflammasome-induced pyroptosis.
Inhibition of MLKL-dependent necroptosis via downregulating interleukin-1R1 contributes to neuroprotection of hypoxic preconditioning in transient global cerebral ischemic rats.
Title: Inhibition of MLKL-dependent necroptosis via downregulating interleukin-1R1 contributes to neuroprotection of hypoxic preconditioning in transient global cerebral ischemic rats.
Role of macrophage-mediated Toll-like receptor 4-interleukin-1R signaling in ectopic tongue pain associated with tooth pulp inflammation.
Title: Role of macrophage-mediated Toll-like receptor 4-interleukin-1R signaling in ectopic tongue pain associated with tooth pulp inflammation.
An increase in expression of IL-1R1 was found in neurons of spinal dorsal horn in an inflammatory pain model.
Title: Interleukin-1 receptor type 1 is overexpressed in neurons but not in glial cells within the rat superficial spinal dorsal horn in complete Freund adjuvant-induced inflammatory pain.
The work identifies a pathogenic role of postnatal IL1b/IL-1R1 pathway and subsequent prolonged prominent increase of endocannabinoid signaling in adult seizure susceptibility following prolonged febrile seizures.
Title: Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling.
Activity of Il-1 in parturition is regulated by progesterone via Il1R1/Il1R2/Il-1RAcp pathway.
Title: Interleukin (IL)-1 in rat parturition: IL-1 receptors 1 and 2 and accessory proteins abundance in pregnant rat uterus at term - regulation by progesterone.
IL-1beta-induced proliferation is possibly mediated by the IL-1R1, JNK, and AP-1 pathways in rat hepatic stellate cells.
Title: Mechanism of interleukin-1β-induced proliferation in rat hepatic stellate cells from different levels of signal transduction.
In the amygdala significant up-regulation of interleukin-1 receptor 1 (IL1r1), interleukin-4 receptor (IL4r), fibroblast growth factor 13 (FGF13), and cathepsin-H (CtsH) was observed in males in response to the odor of cornnuts only.
Title: Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus.
YiGanKang Decoction could not decrease IL-1RI expression, but it could inhibit activity of AP-1 in rat HSCs induced by IL-1beta.
Title: Differential role of YiGanKang decoction in IL-1β induction of IL-1RI and AP-1 in rat hepatic stellate cell.
Data show that IL-1RI and its accessory proteins MyD88 and IL-1RAcP are differently distributed in the hippocampus and in the subcellular compartments of primary hippocampal neurons.
Title: Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94740 (e-PCR)
- UniSTS:119987

RH94741 (e-PCR)
- UniSTS:119988

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD+ nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables interleukin-1 binding	IEA Inferred from Electronic Annotation more info
enables interleukin-1 binding	ISO Inferred from Sequence Orthology more info
enables interleukin-1 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-1 receptor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-1, type I, activating receptor activity	IEA Inferred from Electronic Annotation more info
enables ionotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables platelet-derived growth factor receptor binding	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in heat acclimation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-1-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-1-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-1-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 cell cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T-helper 1 cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 cell cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-1-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neutrophil extravasation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of neutrophil extravasation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in response to epidermal growth factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in response to nitric oxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to odorant	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to transforming growth factor beta	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interleukin-1 receptor type 1

Names: CD121 antigen-like family member A; interleukin 1 beta receptor type 1 short transmembrane form; interleukin 1 beta receptor type 1 soluble form; interleukin 1 bete receptor type 1 long transmembrane form; interleukin-1 receptor alpha; interleukin-1 receptor type I

NP_001399522.1

EC 3.2.2.6

NP_001399523.1

EC 3.2.2.6

XP_006244809.1

EC 3.2.2.6

XP_006244810.1

EC 3.2.2.6

XP_006244811.1

EC 3.2.2.6

XP_006244812.1

EC 3.2.2.6

XP_006244813.1

EC 3.2.2.6

XP_006244814.1

EC 3.2.2.6

XP_008765215.1

EC 3.2.2.6

XP_038939020.1

EC 3.2.2.6

XP_063122809.1

EC 3.2.2.6

XP_063122810.1

EC 3.2.2.6

XP_063122811.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412593.1 → NP_001399522.1 interleukin-1 receptor type 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q02955

UniProtKB/TrEMBL

Q05KR0
NM_001412594.1 → NP_001399523.1 interleukin-1 receptor type 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q02955

UniProtKB/TrEMBL

Q05KR0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

50000558..50076579

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063266739.1 → XP_063122809.1 interleukin-1 receptor type 1 isoform X3

UniProtKB/Swiss-Prot

Q02955

UniProtKB/TrEMBL

Q05KR0
XM_063266741.1 → XP_063122811.1 interleukin-1 receptor type 1 isoform X3

UniProtKB/Swiss-Prot

Q02955

UniProtKB/TrEMBL

Q05KR0
XM_063266740.1 → XP_063122810.1 interleukin-1 receptor type 1 isoform X3

UniProtKB/Swiss-Prot

Q02955

UniProtKB/TrEMBL

Q05KR0
XM_006244747.5 → XP_006244809.1 interleukin-1 receptor type 1 isoform X1

See identical proteins and their annotated locations for XP_006244809.1

UniProtKB/Swiss-Prot

Q02955

UniProtKB/TrEMBL

A6INN1, F7FMA2, Q05KR1

Related

ENSRNOP00000019673.3, ENSRNOT00000019673.6

Conserved Domains (5) summary

cd05757
Location:144 → 236

Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

smart00255
Location:401 → 556

TIR; Toll - interleukin 1 - resistance

smart00410
Location:251 → 344

IG_like; Immunoglobulin like

pfam13927
Location:242 → 333

Ig_3; Immunoglobulin domain

cl11960
Location:47 → 130

Ig; Immunoglobulin domain
XM_006244752.5 → XP_006244814.1 interleukin-1 receptor type 1 isoform X3

See identical proteins and their annotated locations for XP_006244814.1

UniProtKB/Swiss-Prot

Q02955

UniProtKB/TrEMBL

Q05KR0

Conserved Domains (4) summary

smart00255
Location:384 → 539

TIR; Toll - interleukin 1 - resistance

cd00096
Location:128 → 133

Ig; Ig strand A [structural motif]

cd20932
Location:226 → 329

Ig3_IL1R_like; Third immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:128 → 217

Ig; Immunoglobulin domain
XM_006244748.5 → XP_006244810.1 interleukin-1 receptor type 1 isoform X2

See identical proteins and their annotated locations for XP_006244810.1

UniProtKB/Swiss-Prot

Q02955

UniProtKB/TrEMBL

A0A0G2K6N4, A6INM9

Related

ENSRNOP00000073880.1, ENSRNOT00000082146.3

Conserved Domains (5) summary

cd05757
Location:130 → 222

Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

smart00255
Location:387 → 542

TIR; Toll - interleukin 1 - resistance

smart00410
Location:237 → 330

IG_like; Immunoglobulin like

pfam13927
Location:228 → 319

Ig_3; Immunoglobulin domain

cl11960
Location:33 → 116

Ig; Immunoglobulin domain
XM_039083092.2 → XP_038939020.1 interleukin-1 receptor type 1 isoform X3

UniProtKB/Swiss-Prot

Q02955

UniProtKB/TrEMBL

Q05KR0

Related

ENSRNOP00000075417.2, ENSRNOT00000087112.3

Conserved Domains (4) summary

smart00255
Location:384 → 539

TIR; Toll - interleukin 1 - resistance

cd00096
Location:128 → 133

Ig; Ig strand A [structural motif]

cd20932
Location:226 → 329

Ig3_IL1R_like; Third immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:128 → 217

Ig; Immunoglobulin domain
XM_006244750.5 → XP_006244812.1 interleukin-1 receptor type 1 isoform X3

See identical proteins and their annotated locations for XP_006244812.1

UniProtKB/Swiss-Prot

Q02955

UniProtKB/TrEMBL

Q05KR0

Conserved Domains (4) summary

smart00255
Location:384 → 539

TIR; Toll - interleukin 1 - resistance

cd00096
Location:128 → 133

Ig; Ig strand A [structural motif]

cd20932
Location:226 → 329

Ig3_IL1R_like; Third immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:128 → 217

Ig; Immunoglobulin domain
XM_006244749.5 → XP_006244811.1 interleukin-1 receptor type 1 isoform X3

See identical proteins and their annotated locations for XP_006244811.1

UniProtKB/Swiss-Prot

Q02955

UniProtKB/TrEMBL

Q05KR0

Related

ENSRNOP00000072248.3, ENSRNOT00000082408.3

Conserved Domains (4) summary

smart00255
Location:384 → 539

TIR; Toll - interleukin 1 - resistance

cd00096
Location:128 → 133

Ig; Ig strand A [structural motif]

cd20932
Location:226 → 329

Ig3_IL1R_like; Third immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:128 → 217

Ig; Immunoglobulin domain
XM_008766993.3 → XP_008765215.1 interleukin-1 receptor type 1 isoform X3

See identical proteins and their annotated locations for XP_008765215.1

UniProtKB/Swiss-Prot

Q02955

UniProtKB/TrEMBL

Q05KR0

Conserved Domains (4) summary

smart00255
Location:384 → 539

TIR; Toll - interleukin 1 - resistance

cd00096
Location:128 → 133

Ig; Ig strand A [structural motif]

cd20932
Location:226 → 329

Ig3_IL1R_like; Third immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:128 → 217

Ig; Immunoglobulin domain
XM_006244751.4 → XP_006244813.1 interleukin-1 receptor type 1 isoform X3

See identical proteins and their annotated locations for XP_006244813.1

UniProtKB/Swiss-Prot

Q02955

UniProtKB/TrEMBL

Q05KR0

Conserved Domains (4) summary

smart00255
Location:384 → 539

TIR; Toll - interleukin 1 - resistance

cd00096
Location:128 → 133

Ig; Ig strand A [structural motif]

cd20932
Location:226 → 329

Ig3_IL1R_like; Third immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:128 → 217

Ig; Immunoglobulin domain