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    Gnl2 G protein nucleolar 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362593, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gnl2provided by RGD
    Official Full Name
    G protein nucleolar 2provided by RGD
    Primary source
    RGD:1305006
    See related
    EnsemblRapid:ENSRNOG00000009430 AllianceGenome:RGD:1305006
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305006
    Summary
    Predicted to enable GTP binding activity. Predicted to be active in nucleolus. Orthologous to human GNL2 (G protein nucleolar 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 209.5), Kidney (RPKM 119.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gnl2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (142577798..142603185)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (137293141..137318528)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (143027970..143053418)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene R-spondin 1 Neighboring gene uncharacterized LOC108351029 Neighboring gene dynein, axonemal, light intermediate chain 1 Neighboring gene Smad nuclear interacting protein 1 Neighboring gene MYST/Esa1-associated factor 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Coupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export. Matsuo Y, et al. Nature, 2014 Jan 2. PMID 24240281, Free PMC Article
    2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116342

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar GTP-binding protein 2
    Names
    guanine nucleotide binding protein-like 2 (nucleolar)
    nucleolar GTPase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025736.1 → NP_001020907.1  nucleolar GTP-binding protein 2

      See identical proteins and their annotated locations for NP_001020907.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099173
      UniProtKB/TrEMBL
      Q4KLJ3
      Related
      ENSRNOP00000012702.5, ENSRNOT00000012702.8
      Conserved Domains (3) summary
      cd01858
      Location:209 → 365
      NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
      COG1161
      Location:190 → 488
      RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
      pfam08153
      Location:44 → 174
      NGP1NT; NGP1NT (NUC091) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      142577798..142603185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110345.2 → XP_038966273.1  nucleolar GTP-binding protein 2 isoform X1

      Conserved Domains (2) summary
      cd01858
      Location:50 → 206
      NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
      COG1160
      Location:157 → 262
      Der; Predicted GTPases [General function prediction only]
    Nucleotide Protein Strain
    Heading Accession and Version

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