U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dhx29 DExH-box helicase 29 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100362324, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Dhx29provided by RGD
    Official Full Name
    DExH-box helicase 29provided by RGD
    Primary source
    RGD:2318361
    See related
    EnsemblRapid:ENSRNOG00000010369 AllianceGenome:RGD:2318361
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including nucleic acid binding activity; ribonucleoside triphosphate phosphatase activity; and ribosomal small subunit binding activity. Predicted to be involved in formation of translation preinitiation complex and ribosome assembly. Predicted to be part of cytosolic small ribosomal subunit and eukaryotic 43S preinitiation complex. Orthologous to human DHX29 (DExH-box helicase 29). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 72.7), Thymus (RPKM 70.2) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Dhx29 in Genome Data Viewer
    Location:
    2q14
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (46293901..46344652)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (44560653..44611450)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (44787066..44837834)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100707 Neighboring gene phospholipid phosphatase 1 Neighboring gene Mtr4 exosome RNA helicase Neighboring gene multiciliate differentiation and DNA synthesis associated cell cycle protein Neighboring gene cyclin O

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29. Hashem Y, et al. Cell, 2013 May 23. PMID 23706745, Free PMC Article
    2. Roles of individual domains in the function of DHX29, an essential factor required for translation of structured mammalian mRNAs. Dhote V, et al. Proc Natl Acad Sci U S A, 2012 Nov 13. PMID 23047696, Free PMC Article
    3. The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis. Parsyan A, et al. Proc Natl Acad Sci U S A, 2009 Dec 29. PMID 20018725, Free PMC Article
    4. mRNA helicases: the tacticians of translational control. Parsyan A, et al. Nat Rev Mol Cell Biol, 2011 Apr. PMID 21427765
    5. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal small subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in formation of translation preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic 43S preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ATP-dependent RNA helicase DHX29
    Names
    DEAH (Asp-Glu-Ala-His) box polypeptide 29
    DEAH-box helicase 29
    NP_001414443.1
    XP_006232012.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427514.1 → NP_001414443.1  ATP-dependent RNA helicase DHX29

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6G8D3, D3ZHW0
      Related
      ENSRNOP00000013854.6, ENSRNOT00000013854.10

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      46293901..46344652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231950.5 → XP_006232012.1  ATP-dependent RNA helicase DHX29 isoform X1

      See identical proteins and their annotated locations for XP_006232012.1

      UniProtKB/TrEMBL
      A0A8I6G8D3
      Related
      ENSRNOP00000109199.1, ENSRNOT00000140602.1
      Conserved Domains (5) summary
      smart00487
      Location:578 → 764
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:1056 → 1137
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:589 → 736
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:864 → 985
      Helicase_C; Helicase conserved C-terminal domain
      pfam07717
      Location:1179 → 1299
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools