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    Cdk2ap1 cyclin-dependent kinase 2 associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360804, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cdk2ap1provided by RGD
    Official Full Name
    cyclin-dependent kinase 2 associated protein 1provided by RGD
    Primary source
    RGD:1308664
    See related
    EnsemblRapid:ENSRNOG00000001070 AllianceGenome:RGD:1308664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA polymerase binding activity. Predicted to be involved in positive regulation of protein phosphorylation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within face morphogenesis and in utero embryonic development. Predicted to be located in several cellular components, including chromatin; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of NuRD complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human CDK2AP1 (cyclin dependent kinase 2 associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 222.5), Thymus (RPKM 186.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdk2ap1 in Genome Data Viewer
    Location:
    12q15
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (37910718..37919446)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (32249752..32258483)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (37668369..37677067)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene lysine methyltransferase 5A Neighboring gene strawberry notch homolog 1 Neighboring gene mitochondrial translation release factor in rescue Neighboring gene M-phase phosphoprotein 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Targeted inactivation of p12, CDK2 associating protein 1, leads to early embryonic lethality. Kim Y, et al. PLoS One, 2009. PMID 19229340, Free PMC Article
    2. Cloning, mapping, expression, function, and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene Doc-1. Tsuji T, et al. J Biol Chem, 1998 Mar 20. PMID 9506968
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within face morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of NuRD complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 2-associated protein 1
    Names
    CDK2 (cyclin-dependent kinase 2)-associated protein 1
    CDK2-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113751.2 → NP_001107223.1  cyclin-dependent kinase 2-associated protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001107223.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      B0BN48, F7F7G5
      Related
      ENSRNOP00000078090.1, ENSRNOT00000107655.2
      Conserved Domains (1) summary
      pfam09806
      Location:61 → 113
      CDK2AP; Cyclin-dependent kinase 2-associated protein

    2. NM_001401014.1 → NP_001387943.1  cyclin-dependent kinase 2-associated protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      37910718..37919446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271533.1 → XP_063127603.1  cyclin-dependent kinase 2-associated protein 1 isoform X2

      Related
      ENSRNOP00000001419.6, ENSRNOT00000001419.7

    2. XM_008769239.4 → XP_008767461.1  cyclin-dependent kinase 2-associated protein 1 isoform X2

      See identical proteins and their annotated locations for XP_008767461.1

      Conserved Domains (1) summary
      pfam09806
      Location:34 → 86
      CDK2AP; Cyclin-dependent kinase 2-associated protein

    3. XM_039089595.2 → XP_038945523.1  cyclin-dependent kinase 2-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A030
      Related
      ENSRNOP00000084668.1, ENSRNOT00000100788.2
      Conserved Domains (1) summary
      pfam09806
      Location:127 → 179
      CDK2AP; Cyclin-dependent kinase 2-associated protein
    Nucleotide Protein Strain
    Heading Accession and Version

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