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    Ctsh cathepsin H [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25425, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ctshprovided by RGD
    Official Full Name
    cathepsin Hprovided by RGD
    Primary source
    RGD:2447
    See related
    EnsemblRapid:ENSRNOG00000014064 AllianceGenome:RGD:2447
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables aminopeptidase activity; identical protein binding activity; and kininogen binding activity. Involved in several processes, including cellular response to thyroid hormone stimulus; response to odorant; and spermatogenesis. Located in cytoskeleton; extracellular space; and secretory granule. Biomarker of polycystic kidney disease. Orthologous to human CTSH (cathepsin H). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 3767.7), Lung (RPKM 1651.2) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ctsh in Genome Data Viewer
    Location:
    8q31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (99488756..99507639)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (90608941..90627824)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (97439155..97458293)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094224 Neighboring gene ribosomal protein S24, pseudogene 11 Neighboring gene uncharacterized LOC120094225 Neighboring gene mortality factor 4 like 1 Neighboring gene transfer RNA lysine (anticodon CUU) 18

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables HLA-A specific activating MHC class I receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables HLA-A specific activating MHC class I receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables HLA-A specific activating MHC class I receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables aminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type endopeptidase activator activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type endopeptidase activator activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type endopeptidase activator activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type endopeptidase activator activity involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kininogen binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables peptidase activator activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables thyroid hormone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables thyroid hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables thyroid hormone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in T cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T cell mediated cytotoxicity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adaptive immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bradykinin catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bradykinin catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bradykinin catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to thyroid hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to thyroid hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to thyroid hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dichotomous subdivision of terminal units involved in lung branching ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dichotomous subdivision of terminal units involved in lung branching ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response-regulating signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in immune response-regulating signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in immune response-regulating signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in membrane protein proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane protein proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane protein proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in metanephros development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuropeptide catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuropeptide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuropeptide catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein destabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to odorant IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to retinoic acid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in surfactant homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in surfactant homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in surfactant homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in zymogen activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in zymogen activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in zymogen activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in alveolar lamellar body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in alveolar lamellar body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in alveolar lamellar body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in alveolar lamellar body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in outer dense fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    pro-cathepsin H
    Names
    cathepsin B3
    cathepsin BA
    NP_037071.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012939.2NP_037071.1  pro-cathepsin H precursor

      See identical proteins and their annotated locations for NP_037071.1

      Status: VALIDATED

      Source sequence(s)
      FM059929, FM135658, FN800263, JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P00786
      UniProtKB/TrEMBL
      A0A0H2UHL6, A6I215
      Related
      ENSRNOP00000074611.3, ENSRNOT00000080142.3
      Conserved Domains (2) summary
      pfam00112
      Location:115330
      Peptidase_C1; Papain family cysteine protease
      pfam08246
      Location:3388
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      99488756..99507639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)