Slc25a27 solute carrier family 25, member 27 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc25a27provided by RGD
Official Full Name: solute carrier family 25, member 27provided by RGD
Primary source: RGD:620787
See related: EnsemblRapid:ENSRNOG00000010592 AllianceGenome:RGD:620787
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ucp4
Summary: Predicted to enable chloride transmembrane transporter activity; protein homodimerization activity; and proton transmembrane transporter activity. Involved in several processes, including intracellular triglyceride homeostasis; negative regulation of mitochondrial calcium ion concentration; and negative regulation of mitochondrial membrane potential. Located in apical part of cell and neuronal cell body. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SLC25A27 (solute carrier family 25 member 27). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 56.5), Testes (RPKM 9.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q13

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (24804183..24831219)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (17306898..17333942)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (19880468..19907506)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Silencing of UCP4 in primary chondrocytes significantly inhibited cell survival, but induced reactive oxygen species production and cell apoptosis.
Title: Effects of UCP4 on the Proliferation and Apoptosis of Chondrocytes: Its Possible Involvement and Regulation in Osteoarthritis.
A compensatory effect was found for UCP-4 (and UCP-2) in the brain during chronic alcohol consumption.
Title: Chronic alcohol consumption increases the expression of uncoupling protein-2 and -4 in the brain.
After high altitude exposure, UCP-4 mRNA abundance is 2.9-fold compared with the control; UCP-5 mRNA abundance is 2.3-fold compared with the control.
Title: Evidence for involvement of uncoupling proteins in cerebral mitochondrial oxidative phosphorylation deficiency of rats exposed to 5,000 m high altitude.
Data demonstrate that UCP4 expression is differently regulated during postnatal stages and is region-specific, and may play an important role in functional maturation of the rat inner ear.
Title: Role of mitochondrial uncoupling protein 4 in rat inner ear.
UCP4 overexpression reduced the insulin sensitivity and mitochondrial fatty acid oxidation of L6 myocytes.
Title: UCP4 overexpression improves fatty acid oxidation and insulin sensitivity in L6 myocytes.
expression levels are higher in aged female brain as compared to male one
Title: Sex-dependent differences in aged rat brain mitochondrial function and oxidative stress.
Mitochondrial UCPs (UCP2, UCP3, UCP4) may play both a protective role against oxidative damage and a thermal signaling role in the eighth nerve.
Title: Localization of the mitochondrial uncoupling protein family in the rat inner ear.
Results suggest that mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.
Title: Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chloride transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables proton transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in inner ear development	IEP Inferred from Expression Pattern more info	PubMed
involved_in intracellular triglyceride homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitochondrial calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitochondrial membrane potential	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of D-glucose import	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cold	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mitochondrial uncoupling protein 4

Names: uncoupling protein UCP-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053500.2 → NP_445952.1 mitochondrial uncoupling protein 4

See identical proteins and their annotated locations for NP_445952.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A6JJ28, A6JJ30, F7F692, Q9EPH7

Related

ENSRNOP00000039207.4, ENSRNOT00000052068.5

Conserved Domains (2) summary

PTZ00169
Location:22 → 316

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:122 → 218

Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

24804183..24831219

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006244610.5 → XP_006244672.1 mitochondrial uncoupling protein 4 isoform X1

See identical proteins and their annotated locations for XP_006244672.1

UniProtKB/TrEMBL

A6JJ28, Q9EPH5

Conserved Domains (1) summary

pfam00153
Location:122 → 218

Mito_carr; Mitochondrial carrier protein
XM_006244611.5 → XP_006244673.1 mitochondrial uncoupling protein 4 isoform X2

See identical proteins and their annotated locations for XP_006244673.1

UniProtKB/TrEMBL

A0A8I6ALR4, Q9EPH6

Conserved Domains (1) summary

pfam00153
Location:122 → 218

Mito_carr; Mitochondrial carrier protein
XM_006244612.5 → XP_006244674.1 mitochondrial uncoupling protein 4 isoform X4

UniProtKB/TrEMBL

A6JJ28

Conserved Domains (2) summary

PTZ00169
Location:22 → 306

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:122 → 218

Mito_carr; Mitochondrial carrier protein
XM_039084299.2 → XP_038940227.1 mitochondrial uncoupling protein 4 isoform X5

Conserved Domains (1) summary

pfam00153
Location:75 → 171

Mito_carr; Mitochondrial carrier protein
XM_039084303.2 → XP_038940231.1 mitochondrial uncoupling protein 4 isoform X8

Conserved Domains (1) summary

pfam00153
Location:136 → 232

Mito_carr; Mitochondrial carrier protein
XM_039084300.2 → XP_038940228.1 mitochondrial uncoupling protein 4 isoform X5

Conserved Domains (1) summary

pfam00153
Location:75 → 171

Mito_carr; Mitochondrial carrier protein
XM_063267787.1 → XP_063123857.1 mitochondrial uncoupling protein 4 isoform X6

UniProtKB/TrEMBL

Q6R5J6

Related

ENSRNOP00000094770.2, ENSRNOT00000098372.2
XM_008766882.4 → XP_008765104.2 mitochondrial uncoupling protein 4 isoform X3

Conserved Domains (1) summary

pfam00153
Location:93 → 189

Mito_carr; Mitochondrial carrier protein
XM_039084302.2 → XP_038940230.1 mitochondrial uncoupling protein 4 isoform X7

Conserved Domains (1) summary

pfam00153
Location:18 → 114

Mito_carr; Mitochondrial carrier protein