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    Cebpe CCAAT/enhancer binding protein epsilon [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25410, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cebpeprovided by RGD
    Official Full Name
    CCAAT/enhancer binding protein epsilonprovided by RGD
    Primary source
    RGD:2329
    See related
    EnsemblRapid:ENSRNOG00000014282 AllianceGenome:RGD:2329
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CRP1; C/EPBe
    Summary
    Enables DNA binding activity and identical protein binding activity. Involved in cellular response to lipopolysaccharide and myeloid cell differentiation. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of RNA polymerase II transcription regulator complex. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human CEBPE (CCAAT enhancer binding protein epsilon). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 16.3), Lung (RPKM 5.7) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Cebpe in Genome Data Viewer
    Location:
    15p13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32139716..32141476, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28169711..28171471, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33356119..33357517, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene apoptotic chromatin condensation inducer 1 Neighboring gene similar to human chromosome 14 open reading frame 119 Neighboring gene ciliated left-right organizer metallopeptidase Neighboring gene uncharacterized LOC120096982 Neighboring gene solute carrier family 7 member 8 Neighboring gene uncharacterized LOC134482118

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    CCAAT/enhancer-binding protein epsilon
    Names
    CCAAT/enhancer binding protein (C/EBP), epsilon
    CCAAT/enhancer binding protein , epsilon
    c/EBP epsilon
    c/EBP-related protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017095.2NP_058791.1  CCAAT/enhancer-binding protein epsilon

      See identical proteins and their annotated locations for NP_058791.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      P56261
      UniProtKB/TrEMBL
      A6KGV9
      Related
      ENSRNOP00000019154.1, ENSRNOT00000019155.5
      Conserved Domains (1) summary
      cd14715
      Location:202262
      bZIP_CEBPE; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein epsilon (CEBPE): a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      32139716..32141476 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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