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    Ell2 elongation factor for RNA polymerase II 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309918, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ell2provided by RGD
    Official Full Name
    elongation factor for RNA polymerase II 2provided by RGD
    Primary source
    RGD:1309296
    See related
    EnsemblRapid:ENSRNOG00000027089 AllianceGenome:RGD:1309296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription elongation by RNA polymerase II and snRNA transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of transcription elongation factor complex. Orthologous to human ELL2 (elongation factor for RNA polymerase II 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 145.8), Testes (RPKM 112.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ell2 in Genome Data Viewer
    Location:
    2q11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (6910446..6990654)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (5189375..5258781)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (2456189..2525590)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548988 Neighboring gene small nucleolar RNA SNORA24 Neighboring gene small nuclear ribonucleoprotein Sm D1-like Neighboring gene integrin subunit beta 3 binding protein, pseudogene 1 Neighboring gene glutathione S-transferase kappa 1-like Neighboring gene glutaredoxin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The super elongation complex (SEC) family in transcriptional control. Luo Z, et al. Nat Rev Mol Cell Biol, 2012 Sep. PMID 22895430
    2. The little elongation complex regulates small nuclear RNA transcription. Smith ER, et al. Mol Cell, 2011 Dec 23. PMID 22195968, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase II elongation factor ELL2
    Names
    elongation factor RNA for polymerase II 2
    elongation factor RNA polymerase II 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427210.1 → NP_001414139.1  RNA polymerase II elongation factor ELL2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6A5G5, A6I4E9
      Related
      ENSRNOP00000087256.2, ENSRNOT00000108554.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      6910446..6990654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760604.3 → XP_008758826.1  RNA polymerase II elongation factor ELL2 isoform X1

      See identical proteins and their annotated locations for XP_008758826.1

      UniProtKB/TrEMBL
      A0A8I6A5C9
      Conserved Domains (2) summary
      pfam07303
      Location:466 → 567
      Occludin_ELL; Occludin homology domain
      pfam10390
      Location:1 → 225
      ELL; RNA polymerase II elongation factor ELL

    2. XM_039103371.2 → XP_038959299.1  RNA polymerase II elongation factor ELL2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5C9
      Conserved Domains (2) summary
      pfam07303
      Location:466 → 567
      Occludin_ELL; Occludin homology domain
      pfam10390
      Location:1 → 225
      ELL; RNA polymerase II elongation factor ELL

    RNA

    1. XR_010063598.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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