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    Tmem230 transmembrane protein 230 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681315, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem230provided by RGD
    Official Full Name
    transmembrane protein 230provided by RGD
    Primary source
    RGD:1307399
    See related
    AllianceGenome:RGD:1307399
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307399
    Summary
    Predicted to be involved in axonal transport and synaptic vesicle transport. Is active in synaptic vesicle membrane. Orthologous to human TMEM230 (transmembrane protein 230). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 134.2), Muscle (RPKM 114.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem230 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (139925878..139950517, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (119473109..119497617, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (124870867..124879274, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552722 Neighboring gene solute carrier family 23 member 2 Neighboring gene choline/ethanolamine kinase-like Neighboring gene proliferating cell nuclear antigen Neighboring gene CDP-diacylglycerol synthase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of TMEM230 mutations in familial Parkinson's disease. Deng HX, et al. Nat Genet, 2016 Jul. PMID 27270108, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in axonal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 230
    Names
    HSPC274 protein
    UPF0414 transmembrane protein C20orf30 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048043.1 → NP_001041508.1  transmembrane protein 230

      See identical proteins and their annotated locations for NP_001041508.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105614
      UniProtKB/Swiss-Prot
      Q0VGK9, Q5BJP5
      UniProtKB/TrEMBL
      A6HQF7
      Conserved Domains (1) summary
      pfam05915
      Location:2 → 118
      DUF872; Eukaryotic protein of unknown function (DUF872)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      139925878..139950517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105858.2 → XP_038961786.1  transmembrane protein 230 isoform X2

    2. XM_006235070.5 → XP_006235132.1  transmembrane protein 230 isoform X1

      See identical proteins and their annotated locations for XP_006235132.1

      UniProtKB/Swiss-Prot
      Q0VGK9, Q5BJP5
      UniProtKB/TrEMBL
      A6HQF7
      Conserved Domains (1) summary
      pfam05915
      Location:2 → 118
      DUF872; Eukaryotic protein of unknown function (DUF872)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BJP5.1 GenPept UniProtKB/Swiss-Prot:Q5BJP5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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