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    Naa35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64472, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Naa35provided by RGD
    Official Full Name
    N(alpha)-acetyltransferase 35, NatC auxiliary subunitprovided by RGD
    Primary source
    RGD:621771
    See related
    EnsemblRapid:ENSRNOG00000018417 AllianceGenome:RGD:621771
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    T4a; Mak10
    Summary
    Predicted to be involved in negative regulation of apoptotic process and smooth muscle cell proliferation. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of NatC complex. Orthologous to human NAA35 (N-alpha-acetyltransferase 35, NatC auxiliary subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 114.4), Adrenal (RPKM 104.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Naa35 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (5039897..5091916, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (5034360..5086456, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (5411479..5463898, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 9 open reading frame 153 Neighboring gene uncharacterized LOC134482661 Neighboring gene golgi membrane protein 1 Neighboring gene serine/arginine repetitive matrix protein 3-like Neighboring gene ATP/GTP binding carboxypeptidase 1 Neighboring gene uncharacterized LOC134482764

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Synaptonemal complexes from DNase-treated rat pachytene chromosomes contain (GT)n and LINE/SINE sequences. Pearlman RE, et al. Genetics, 1992 Apr. PMID 1582563, Free PMC Article
    2. A novel epithelial wound-related gene is abundantly expressed in developing rat cornea and skin. Yi XJ, et al. Curr Eye Res, 2000 May. PMID 10855038
    3. Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development. Wenzlau JM, et al. Circ Res, 2006 Mar 31. PMID 16484612
    4. Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization. Starheim KK, et al. Mol Cell Biol, 2009 Jul. PMID 19398576, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in smooth muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of NatC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatC complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of NatC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of NatC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N-alpha-acetyltransferase 35, NatC auxiliary subunit
    Names
    RAT52
    corneal wound-healing-related protein
    embryonic growth-associated protein
    protein MAK10 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133324.2 → NP_579858.2  N-alpha-acetyltransferase 35, NatC auxiliary subunit

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      Q6DKG0, Q9JI01
      UniProtKB/TrEMBL
      A0A8L2R6B2, A6KAI2
      Related
      ENSRNOP00000025096.4, ENSRNOT00000025096.6
      Conserved Domains (1) summary
      pfam04112
      Location:46 → 181
      Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      5039897..5091916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253526.5 → XP_006253588.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X1

      See identical proteins and their annotated locations for XP_006253588.1

      UniProtKB/Swiss-Prot
      Q6DKG0, Q9JI01
      UniProtKB/TrEMBL
      A0A8L2R6B2, A6KAI2
      Conserved Domains (1) summary
      pfam04112
      Location:46 → 181
      Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

    2. XM_006253527.4 → XP_006253589.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X2

      UniProtKB/TrEMBL
      A0A8L2QDG7
      Conserved Domains (1) summary
      pfam04112
      Location:1 → 122
      Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DKG0.1 GenPept UniProtKB/Swiss-Prot:Q6DKG0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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