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    rpl6 ribosomal protein L6 [ Danio rerio (zebrafish) ]

    Gene ID: 336727, updated on 4-Jan-2025

    Summary

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    Official Symbol
    rpl6provided by ZNC
    Official Full Name
    ribosomal protein L6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8671
    See related
    Ensembl:ENSDARG00000058451 AllianceGenome:ZFIN:ZDB-GENE-030131-8671
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fa93h05; wu:fb26a11; zgc:111805
    Summary
    Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Acts upstream of or within chordate embryonic development and pancreas development. Predicted to be located in ribosome. Predicted to be part of cytosolic large ribosomal subunit. Is expressed in digestive system; endodermal cell; epithelial cell of pancreas; and lens. Orthologous to human RPL6 (ribosomal protein L6). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See rpl6 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (2493794..2506356, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (2435251..2447813, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:dkeyp-51b9.3 Neighboring gene dynein, light chain, LC8-type 1 Neighboring gene acetyl-CoA acyltransferase 2 Neighboring gene mitochondrial ribosomal protein L40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Single-cell RNA-sequencing uncovers transcriptional states and fate decisions in haematopoiesis. Athanasiadis EI, et al. Nat Commun, 2017 Dec 11. PMID 29229905, Free PMC Article
    2. Identification and expression of carbonic anhydrase 2, myosin regulatory light chain 2 and selenium-binding protein 1 in zebrafish Danio rerio: Implication for age-related biomarkers. Feng S, et al. Gene Expr Patterns, 2018 Sep. PMID 29738878
    3. Ribosomal protein gene knockdown causes developmental defects in zebrafish. Uechi T, et al. PLoS One, 2006 Dec 20. PMID 17183665, Free PMC Article
    4. Multiple ribosomal proteins are expressed at high levels in developing zebrafish endoderm and are required for normal exocrine pancreas development. Provost E, et al. Zebrafish, 2013 Jun. PMID 23697888, Free PMC Article
    5. Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish. Lai K, et al. Dev Dyn, 2009 Jan. PMID 19097187, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC111805

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chordate embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL6
    Names
    60S ribosomal protein L6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003844.2 → NP_001003844.2  large ribosomal subunit protein eL6

      Status: VALIDATED

      Source sequence(s)
      CT573399, EH584073
      UniProtKB/TrEMBL
      A0A0R4ILG7, A0A8N7XJI3, F6NWV4, Q567N5
      Related
      ENSDARP00000091899.4, ENSDART00000101125.5
      Conserved Domains (3) summary
      COG2163
      Location:117 → 241
      RPL14A; Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]
      cd13156
      Location:113 → 265
      KOW_RPL6; KOW motif of Ribosomal Protein L6
      pfam03868
      Location:6 → 48
      Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

    2. NM_001328586.1 → NP_001315515.1  large ribosomal subunit protein eL6

      Status: VALIDATED

      Source sequence(s)
      CT573399, EH584073
      UniProtKB/TrEMBL
      A0A0R4ILG7, A0A8N7XJI3, F6NWV4, Q567N5
      Related
      ENSDARP00000107457.2, ENSDART00000125124.4
      Conserved Domains (3) summary
      COG2163
      Location:117 → 241
      RPL14A; Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]
      cd13156
      Location:113 → 265
      KOW_RPL6; KOW motif of Ribosomal Protein L6
      pfam03868
      Location:6 → 48
      Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      2493794..2506356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222886.1 → XP_068078987.1  large ribosomal subunit protein eL6 isoform X1

      UniProtKB/TrEMBL
      A0A0R4ILG7, A0A8N7XJI3, F6NWV4, Q567N5
      Related
      ENSDARP00000136100.3, ENSDART00000171559.3
    Nucleotide Protein Strain
    Heading Accession and Version

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