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    si:ch211-194k22.8 si:ch211-194k22.8 [ Danio rerio (zebrafish) ]

    Gene ID: 560328, updated on 4-Jan-2025

    Summary

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    Official Symbol
    si:ch211-194k22.8provided by ZNC
    Official Full Name
    si:ch211-194k22.8provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1820
    See related
    Ensembl:ENSDARG00000096711 AllianceGenome:ZFIN:ZDB-GENE-030131-1820
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb81f11; wu:fb81f11
    Summary
    Predicted to enable DNA binding activity and transcription corepressor activity. Predicted to act upstream of or within negative regulation of Notch signaling pathway and positive regulation of neuron differentiation. Orthologous to human BEND6 (BEN domain containing 6). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See si:ch211-194k22.8 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (28839839..28847995, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (28724937..28733108, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene proline rich 15 like b Neighboring gene CDK5 regulatory subunit associated protein 3 Neighboring gene nfe2 like bZIP transcription factor 1b Neighboring gene chromobox homolog 1b (HP1 beta homolog Drosophila)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A gain-of-function screen in zebrafish identifies a guanylate cyclase with a role in neuronal degeneration. Maddison LA, et al. Mol Genet Genomics, 2009 May. PMID 19221799, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BEN domain-containing protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      28839839..28847995 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480353.2 → XP_021336028.1  BEN domain-containing protein 6

      UniProtKB/TrEMBL
      A0A8M9PMF0, A0A8M9Q933, U3JAZ4
      Related
      ENSDARP00000127416.1, ENSDART00000153200.2
      Conserved Domains (1) summary
      pfam10523
      Location:223 → 289
      BEN; BEN domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394848.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      282316..290472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_683728.9 → XP_688820.1  BEN domain-containing protein 6

      UniProtKB/TrEMBL
      A0A8M9PMF0, A0A8M9Q933, U3JAZ4
      Conserved Domains (1) summary
      pfam10523
      Location:223 → 289
      BEN; BEN domain
    Nucleotide Protein
    Heading Accession and Version

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