Gng12 guanine nucleotide binding protein (G protein), gamma 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gng12provided by MGI
Official Full Name: guanine nucleotide binding protein (G protein), gamma 12provided by MGI
Primary source: MGI:MGI:1336171
See related: Ensembl:ENSMUSG00000036402 AllianceGenome:MGI:1336171
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hg3a; 2010305F15Rik
Summary: Predicted to enable G-protein beta-subunit binding activity; PDZ domain binding activity; and phosphate ion binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Is active in synapse. Is expressed in cerebral cortex subventricular zone; genitourinary system; and ventricular layer. Orthologous to human GNG12 (G protein subunit gamma 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 26.2), kidney adult (RPKM 24.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C1; 6 30.68 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (66873381..66998345)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (66896397..67021361)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Modulating Gng12 mRNA levels using RNAi revealed a novel role for the factor in the negative regulation of the overall inflammatory response as based on effects on nitrite and TNFalpha levels.
Title: Gng12 is a novel negative regulator of LPS-induced inflammation in the microglial cell line BV-2.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Z72357 (e-PCR)
- UniSTS:51726

RH124500 (e-PCR)
- UniSTS:161322

Z72358 (e-PCR)
- UniSTS:12197

AI314170 (e-PCR)
- UniSTS:179385

RH135883 (e-PCR)
- UniSTS:209881

AI842738 (e-PCR)
- UniSTS:164326

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G-protein beta-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta-subunit binding	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info	PubMed
enables phosphate ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin filament	ISO Inferred from Sequence Orthology more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IEA Inferred from Electronic Annotation more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Names: heterotrimeric guanine nucleotide-binding protein 3a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177556.1 → NP_001171027.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

See identical proteins and their annotated locations for NP_001171027.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.

Source sequence(s)

AC107650

Consensus CDS

CCDS39502.1

UniProtKB/Swiss-Prot

Q544P3, Q9DAS9

UniProtKB/TrEMBL

A0A0N4SVT3

Related

ENSMUSP00000109863.2, ENSMUST00000114225.8

Conserved Domains (1) summary

smart00224
Location:11 → 72

GGL; G protein gamma subunit-like motifs
NM_001177557.1 → NP_001171028.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

See identical proteins and their annotated locations for NP_001171028.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.

Source sequence(s)

AC107650, AK005561, BB851888

Consensus CDS

CCDS39502.1

UniProtKB/Swiss-Prot

Q544P3, Q9DAS9

UniProtKB/TrEMBL

A0A0N4SVT3

Related

ENSMUSP00000109866.2, ENSMUST00000114228.8

Conserved Domains (1) summary

smart00224
Location:11 → 72

GGL; G protein gamma subunit-like motifs
NM_001177558.1 → NP_001171029.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

See identical proteins and their annotated locations for NP_001171029.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.

Source sequence(s)

AC107650

Consensus CDS

CCDS39502.1

UniProtKB/Swiss-Prot

Q544P3, Q9DAS9

UniProtKB/TrEMBL

A0A0N4SVT3

Related

ENSMUSP00000109860.2, ENSMUST00000114222.4

Conserved Domains (1) summary

smart00224
Location:11 → 72

GGL; G protein gamma subunit-like motifs
NM_001177559.1 → NP_001171030.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

See identical proteins and their annotated locations for NP_001171030.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.

Source sequence(s)

AC107650

Consensus CDS

CCDS39502.1

UniProtKB/Swiss-Prot

Q544P3, Q9DAS9

UniProtKB/TrEMBL

A0A0N4SVT3

Related

ENSMUSP00000109865.2, ENSMUST00000114227.8

Conserved Domains (1) summary

smart00224
Location:11 → 72

GGL; G protein gamma subunit-like motifs
NM_001177560.1 → NP_001171031.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

See identical proteins and their annotated locations for NP_001171031.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.

Source sequence(s)

AC107650, AK162342, BB851888

Consensus CDS

CCDS39502.1

UniProtKB/Swiss-Prot

Q544P3, Q9DAS9

UniProtKB/TrEMBL

A0A0N4SVT3

Related

ENSMUSP00000109864.2, ENSMUST00000114226.8

Conserved Domains (1) summary

smart00224
Location:11 → 72

GGL; G protein gamma subunit-like motifs
NM_025278.5 → NP_079554.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

See identical proteins and their annotated locations for NP_079554.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.

Source sequence(s)

AC107650, AK159872, BB851888

Consensus CDS

CCDS39502.1

UniProtKB/Swiss-Prot

Q544P3, Q9DAS9

UniProtKB/TrEMBL

A0A0N4SVT3

Related

ENSMUSP00000046557.7, ENSMUST00000043148.13

Conserved Domains (1) summary

smart00224
Location:11 → 72

GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

66873381..66998345

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165848.1 → XP_036021741.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1

UniProtKB/Swiss-Prot

Q544P3, Q9DAS9

UniProtKB/TrEMBL

A0A0N4SVT3

Related

ENSMUSP00000109862.2, ENSMUST00000114224.8

Conserved Domains (1) summary

smart00224
Location:11 → 72

GGL; G protein gamma subunit-like motifs
XM_036165846.1 → XP_036021739.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1

UniProtKB/Swiss-Prot

Q544P3, Q9DAS9

UniProtKB/TrEMBL

A0A0N4SVT3

Conserved Domains (1) summary

smart00224
Location:11 → 72

GGL; G protein gamma subunit-like motifs
XM_036165845.1 → XP_036021738.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1

UniProtKB/Swiss-Prot

Q544P3, Q9DAS9

UniProtKB/TrEMBL

A0A0N4SVT3

Conserved Domains (1) summary

smart00224
Location:11 → 72

GGL; G protein gamma subunit-like motifs