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    Krr1 KRR1, small subunit (SSU) processome component, homolog (yeast) [ Mus musculus (house mouse) ]

    Gene ID: 52705, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Krr1provided by MGI
    Official Full Name
    KRR1, small subunit (SSU) processome component, homolog (yeast)provided by MGI
    Primary source
    MGI:MGI:1289274
    See related
    Ensembl:ENSMUSG00000063334 AllianceGenome:MGI:1289274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hrb2; D10Ertd773e; 2610511F02Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in ribosomal small subunit biogenesis. Predicted to be located in chromosome; intercellular bridge; and nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including brain; esophagus; head mesenchyme; sensory organ; and spinal cord. Orthologous to human KRR1 (KRR1 small subunit processome component homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 9.9), bladder adult (RPKM 6.8) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Krr1 in Genome Data Viewer
    Location:
    10 D1- D2; 10 59.97 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (111808600..111824335)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (111972695..111988430)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_27889 Neighboring gene STARR-seq mESC enhancer starr_27890 Neighboring gene STARR-seq mESC enhancer starr_27891 Neighboring gene predicted gene, 20758 Neighboring gene STARR-seq mESC enhancer starr_27892 Neighboring gene STARR-seq mESC enhancer starr_27894 Neighboring gene STARR-positive B cell enhancer mm9_chr10:111362554-111362854 Neighboring gene STARR-positive B cell enhancer ABC_E5182 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:111409583-111409851 Neighboring gene STARR-seq mESC enhancer starr_27895 Neighboring gene STARR-positive B cell enhancer ABC_E2340 Neighboring gene STARR-positive B cell enhancer ABC_E1813 Neighboring gene STARR-positive B cell enhancer ABC_E3914 Neighboring gene GLI pathogenesis related 1 Neighboring gene calcyphosphine 2 pseudogene Neighboring gene GLI pathogenesis-related 1 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    2. Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each. Dogar AM, et al. PLoS One, 2018. PMID 30418981, Free PMC Article
    3. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    KRR1 small subunit processome component homolog
    Names
    HIV-1 Rev binding protein 2
    HIV-1 Rev-binding protein 2 homolog
    KRR-R motif-containing protein 1
    KRR1, small subunit processome component

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178610.4 → NP_848725.2  KRR1 small subunit processome component homolog

      See identical proteins and their annotated locations for NP_848725.2

      Status: VALIDATED

      Source sequence(s)
      AC167231, AK041854, CD547185
      Consensus CDS
      CCDS24168.1
      UniProtKB/Swiss-Prot
      Q3UIG9, Q52KQ6, Q5EBJ5, Q8BGA5, Q8C029
      UniProtKB/TrEMBL
      G3UZA0
      Related
      ENSMUSP00000125746.2, ENSMUST00000163048.8
      Conserved Domains (2) summary
      smart00322
      Location:157 → 207
      KH; K homology RNA-binding domain
      COG1094
      Location:55 → 240
      Krr1; rRNA processing protein Krr1/Pno1, contains KH domain [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      111808600..111824335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGA5.1 GenPept UniProtKB/Swiss-Prot:Q8BGA5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous