Tifa TRAF-interacting protein with forkhead-associated domain [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tifaprovided by RGD
Official Full Name: TRAF-interacting protein with forkhead-associated domainprovided by RGD
Primary source: RGD:1359151
See related: EnsemblRapid:ENSRNOG00000010941 AllianceGenome:RGD:1359151
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: T2bp; Ab2-389
Summary: Predicted to be involved in several processes, including positive regulation of canonical NF-kappaB signal transduction; protein homooligomerization; and tumor necrosis factor-mediated signaling pathway. Predicted to be active in cytoplasm. Orthologous to human TIFA (TRAF interacting protein with forkhead associated domain). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 137.4), Lung (RPKM 50.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q42

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (218927724..218942111)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (216257926..216267635)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (232104394..232137425)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cytoplasmic pattern recognition receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic pattern recognition receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: TRAF-interacting protein with FHA domain-containing protein A

Names: TRAF2-binding protein; Traf2 binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014044.1 → NP_001014066.1 TRAF-interacting protein with FHA domain-containing protein A

See identical proteins and their annotated locations for NP_001014066.1

Status: PROVISIONAL

Source sequence(s)

BC083765

UniProtKB/Swiss-Prot

Q5XIB9

UniProtKB/TrEMBL

A6HVM2

Related

ENSRNOP00000061870.1, ENSRNOT00000014533.8

Conserved Domains (1) summary

cd00060
Location:47 → 129

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

218927724..218942111

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102464.2 → XP_038958392.1 TRAF-interacting protein with FHA domain-containing protein A isoform X1

UniProtKB/Swiss-Prot

Q5XIB9

UniProtKB/TrEMBL

A6HVM2

Conserved Domains (1) summary

cd00060
Location:47 → 129

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
XM_039102463.2 → XP_038958391.1 TRAF-interacting protein with FHA domain-containing protein A isoform X1

UniProtKB/Swiss-Prot

Q5XIB9

UniProtKB/TrEMBL

A6HVM2

Related

ENSRNOP00000105247.1, ENSRNOT00000151568.1

Conserved Domains (1) summary

cd00060
Location:47 → 129

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
XM_039102465.2 → XP_038958393.1 TRAF-interacting protein with FHA domain-containing protein A isoform X1

UniProtKB/Swiss-Prot

Q5XIB9

UniProtKB/TrEMBL

A6HVM2

Related

ENSRNOP00000077082.1, ENSRNOT00000112612.2

Conserved Domains (1) summary

cd00060
Location:47 → 129

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...