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    Pkig cAMP-dependent protein kinase inhibitor gamma [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266709, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pkigprovided by RGD
    Official Full Name
    cAMP-dependent protein kinase inhibitor gammaprovided by RGD
    Primary source
    RGD:628775
    See related
    EnsemblRapid:ENSRNOG00000010235 AllianceGenome:RGD:628775
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables cAMP-dependent protein kinase inhibitor activity. Predicted to act upstream of or within negative regulation of protein import into nucleus; negative regulation of protein kinase activity; and negative regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm and nucleus. Orthologous to human PKIG (cAMP-dependent protein kinase inhibitor gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 124.0), Lung (RPKM 87.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pkig in Genome Data Viewer
    Location:
    3q42
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (172749871..172817514)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (152330477..152398085)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (160047257..160115180)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene alpha tocopherol transfer protein like Neighboring gene serine incorporator 3 Neighboring gene adenosine deaminase Neighboring gene uncharacterized LOC120101472

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Endogenous protein kinase inhibitor gamma terminates immediate-early gene expression induced by cAMP-dependent protein kinase (PKA) signaling: termination depends on PKA inactivation rather than PKA export from the nucleus. Chen X, et al. J Biol Chem, 2005 Jan 28. PMID 15557275
    2. Characterization of PKIgamma, a novel isoform of the protein kinase inhibitor of cAMP-dependent protein kinase. Collins SP, et al. J Biol Chem, 1997 Jul 18. PMID 9218452
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. endogenous levels of PKI regulate PKA signaling
      Title: Endogenous protein kinase inhibitor gamma terminates immediate-early gene expression induced by cAMP-dependent protein kinase (PKA) signaling: termination depends on PKA inactivation rather than PKA export from the nucleus.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108574

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cAMP-dependent protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP-dependent protein kinase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cAMP-dependent protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cAMP-dependent protein kinase inhibitor gamma
    Names
    protein kinase (cAMP-dependent, catalytic) inhibitor gamma
    protein kinase inhibitor, gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401793.1 → NP_001388722.1  cAMP-dependent protein kinase inhibitor gamma

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JX43, A6JX44, Q6YH22
      Related
      ENSRNOP00000108043.1, ENSRNOT00000133815.1

    2. NM_001401794.1 → NP_001388723.1  cAMP-dependent protein kinase inhibitor gamma

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JX43, A6JX44, Q6YH22

    3. NM_001401795.1 → NP_001388724.1  cAMP-dependent protein kinase inhibitor gamma

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JX43, A6JX44, Q6YH22

    4. NM_001401796.1 → NP_001388725.1  cAMP-dependent protein kinase inhibitor gamma

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JX43, A6JX44, Q6YH22

    5. NM_001401797.1 → NP_001388726.1  cAMP-dependent protein kinase inhibitor gamma

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JX43, A6JX44, Q6YH22

    6. NM_153469.5 → NP_703199.1  cAMP-dependent protein kinase inhibitor gamma

      See identical proteins and their annotated locations for NP_703199.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JX43, A6JX44, Q6YH22
      Conserved Domains (1) summary
      pfam02827
      Location:2 → 70
      PKI; cAMP-dependent protein kinase inhibitor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      172749871..172817514
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283175.1 → XP_063139245.1  cAMP-dependent protein kinase inhibitor gamma isoform X3

    2. XM_008762470.4 → XP_008760692.1  cAMP-dependent protein kinase inhibitor gamma isoform X2

      See identical proteins and their annotated locations for XP_008760692.1

      UniProtKB/TrEMBL
      A6JX43, A6JX44, Q6YH22
      Conserved Domains (1) summary
      pfam02827
      Location:2 → 70
      PKI; cAMP-dependent protein kinase inhibitor

    3. XM_063283174.1 → XP_063139244.1  cAMP-dependent protein kinase inhibitor gamma isoform X1

      UniProtKB/TrEMBL
      F7F4X2
    Nucleotide Protein Strain
    Heading Accession and Version

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