U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tmprss15 transmembrane serine protease 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288291, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tmprss15provided by RGD
    Official Full Name
    transmembrane serine protease 15provided by RGD
    Primary source
    RGD:1311046
    See related
    EnsemblRapid:ENSRNOG00000001916 AllianceGenome:RGD:1311046
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prss7
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in enterokinase deficiency. Orthologous to human TMPRSS15 (transmembrane serine protease 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 1.9), Spleen (RPKM 0.5) and 3 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Tmprss15 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (31164633..31289143, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (17677741..17802255, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (17561591..17684903, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095597 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 31 Neighboring gene chondrolectin Neighboring gene olfactory receptor family 5 subfamily B member 129, pseudogene 1 Neighboring gene ribosomal protein L27 like 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mutations in the proenteropeptidase gene are the molecular cause of congenital enteropeptidase deficiency. Holzinger A, et al. Am J Hum Genet, 2002 Jan. PMID 11719902, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    enteropeptidase
    Names
    protease, serine, 7 (enterokinase)
    transmembrane protease, serine 15
    NP_001099365.1
    XP_063126502.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105895.1 → NP_001099365.1  enteropeptidase

      See identical proteins and their annotated locations for NP_001099365.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473989
      UniProtKB/TrEMBL
      A6JL47, D4A911
      Related
      ENSRNOP00000042615.3, ENSRNOT00000051213.5
      Conserved Domains (8) summary
      cd06263
      Location:183 → 338
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00020
      Location:620 → 854
      Tryp_SPc; Trypsin-like serine protease
      smart00202
      Location:514 → 607
      SR; Scavenger receptor Cys-rich
      cd00112
      Location:479 → 513
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:621 → 856
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00431
      Location:360 → 467
      CUB; CUB domain
      pfam00629
      Location:183 → 340
      MAM; MAM domain, meprin/A5/mu
      cl00049
      Location:61 → 167
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      31164633..31289143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270432.1 → XP_063126502.1  enteropeptidase isoform X1

      UniProtKB/TrEMBL
      D4A911
      Related
      ENSRNOP00000111901.1, ENSRNOT00000149657.1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools