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    Armc8 armadillo repeat containing 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315949, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Armc8provided by RGD
    Official Full Name
    armadillo repeat containing 8provided by RGD
    Primary source
    RGD:1310477
    See related
    EnsemblRapid:ENSRNOG00000014521 AllianceGenome:RGD:1310477
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310477
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of GID complex. Orthologous to human ARMC8 (armadillo repeat containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 111.5), Heart (RPKM 97.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Armc8 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (108916274..109010877, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (100036946..100131544, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (107723359..107819208, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480219 Neighboring gene muscle RAS oncogene homolog Neighboring gene NME/NM23 family member 9 Neighboring gene uncharacterized LOC120094240 Neighboring gene debranching RNA lariats 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex. Kobayashi N, et al. Gene, 2007 Jul 15. PMID 17467196
    2. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article
    3. The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation. Lampert F, et al. Elife, 2018 Jun 18. PMID 29911972, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of GID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    armadillo repeat-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173354.3 → NP_001166825.1  armadillo repeat-containing protein 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      B4F7A2, F1M943
      Related
      ENSRNOP00000019536.5, ENSRNOT00000019536.7
      Conserved Domains (4) summary
      COG5064
      Location:49 → 212
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      COG5369
      Location:374 → 668
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00044
      Location:553 → 583
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:57 → 90
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      108916274..109010877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265591.1 → XP_063121661.1  armadillo repeat-containing protein 8 isoform X11

      UniProtKB/TrEMBL
      B4F7A2

    2. XM_063265589.1 → XP_063121659.1  armadillo repeat-containing protein 8 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AI93, B4F7A2
      Related
      ENSRNOP00000093072.1, ENSRNOT00000102972.2

    3. XM_063265588.1 → XP_063121658.1  armadillo repeat-containing protein 8 isoform X7

      UniProtKB/TrEMBL
      B4F7A2

    4. XM_063265592.1 → XP_063121662.1  armadillo repeat-containing protein 8 isoform X12

      UniProtKB/TrEMBL
      B4F7A2

    5. XM_063265590.1 → XP_063121660.1  armadillo repeat-containing protein 8 isoform X10

      UniProtKB/TrEMBL
      A0A8I6GI95, B4F7A2
      Related
      ENSRNOP00000089635.1, ENSRNOT00000115822.2

    6. XM_006243625.5 → XP_006243687.1  armadillo repeat-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      B4F7A2
      Conserved Domains (4) summary
      COG5064
      Location:7 → 170
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      COG5369
      Location:332 → 626
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00044
      Location:511 → 541
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:15 → 48
      ARM; armadillo repeat [structural motif]

    7. XM_039081547.2 → XP_038937475.1  armadillo repeat-containing protein 8 isoform X9

      Conserved Domains (4) summary
      COG5064
      Location:15 → 346
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      COG5369
      Location:272 → 475
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00044
      Location:184 → 223
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:15 → 48
      ARM; armadillo repeat [structural motif]

    8. XM_039081546.2 → XP_038937474.1  armadillo repeat-containing protein 8 isoform X6

      Conserved Domains (3) summary
      COG5064
      Location:7 → 170
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      COG5369
      Location:269 → 504
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00043
      Location:15 → 48
      ARM; armadillo repeat [structural motif]

    9. XM_006243624.5 → XP_006243686.2  armadillo repeat-containing protein 8 isoform X4

      UniProtKB/TrEMBL
      B4F7A2

    10. XM_039081545.2 → XP_038937473.1  armadillo repeat-containing protein 8 isoform X5

      UniProtKB/TrEMBL
      B4F7A2
      Conserved Domains (3) summary
      COG5064
      Location:7 → 170
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      COG5369
      Location:339 → 542
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00043
      Location:15 → 48
      ARM; armadillo repeat [structural motif]

    11. XM_006243623.5 → XP_006243685.2  armadillo repeat-containing protein 8 isoform X3

      UniProtKB/TrEMBL
      B4F7A2

    12. XM_039081544.2 → XP_038937472.1  armadillo repeat-containing protein 8 isoform X2

      UniProtKB/TrEMBL
      B4F7A2
      Conserved Domains (4) summary
      COG5064
      Location:7 → 170
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      COG5369
      Location:332 → 497
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00044
      Location:511 → 551
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:15 → 48
      ARM; armadillo repeat [structural motif]

    13. XM_006243622.5 → XP_006243684.2  armadillo repeat-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      B4F7A2
      Conserved Domains (4) summary
      COG5064
      Location:7 → 170
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      COG5369
      Location:332 → 626
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00044
      Location:511 → 541
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:15 → 48
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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