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    Engase endo-beta-N-acetylglucosaminidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303702, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Engaseprovided by RGD
    Official Full Name
    endo-beta-N-acetylglucosaminidaseprovided by RGD
    Primary source
    RGD:1310868
    See related
    EnsemblRapid:ENSRNOG00000027498 AllianceGenome:RGD:1310868
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310868
    Summary
    Predicted to enable mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity. Predicted to be involved in N-glycan processing. Predicted to act upstream of or within protein deglycosylation. Predicted to be located in cytosol. Orthologous to human ENGASE (endo-beta-N-acetylglucosaminidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 75.1), Thymus (RPKM 58.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Engase in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (104205753..104218416)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (103707169..103719833)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (107502636..107515300)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548791 Neighboring gene C1q and TNF related 1 Neighboring gene RNA binding fox-1 homolog 3 Neighboring gene uncharacterized LOC134480911 Neighboring gene signal recognition particle 19 kDa protein-like Neighboring gene uncharacterized LOC134480909

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Endo-β-N-acetylglucosaminidase forms N-GlcNAc protein aggregates during ER-associated degradation in Ngly1-defective cells. Huang C, et al. Proc Natl Acad Sci U S A, 2015 Feb 3. PMID 25605922, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein deglycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic endo-beta-N-acetylglucosaminidase
    NP_001100540.1
    XP_006247865.1
    XP_006247866.1
    XP_038942141.1
    XP_063125315.1
    XP_063125316.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107070.1 → NP_001100540.1  cytosolic endo-beta-N-acetylglucosaminidase

      See identical proteins and their annotated locations for NP_001100540.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A8I6GLC2, A6HL61
      Conserved Domains (1) summary
      cd06547
      Location:116 → 426
      GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      104205753..104218416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247803.3 → XP_006247865.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLC2, D4AE03
      Conserved Domains (1) summary
      cd06547
      Location:116 → 426
      GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...

    2. XM_063269246.1 → XP_063125316.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X5

    3. XM_039086213.2 → XP_038942141.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X3

      UniProtKB/TrEMBL
      A0A8I6GLC2
      Conserved Domains (1) summary
      cd06547
      Location:27 → 337
      GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...

    4. XM_063269245.1 → XP_063125315.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X4

      UniProtKB/TrEMBL
      A0A8I6GLC2

    5. XM_006247804.5 → XP_006247866.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X2

      UniProtKB/TrEMBL
      A0A8I6GLC2
      Related
      ENSRNOP00000038006.6, ENSRNOT00000038088.7
      Conserved Domains (1) summary
      cd06547
      Location:93 → 403
      GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...

    RNA

    1. XR_005489867.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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