Rab31 RAB31, member RAS oncogene family [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rab31provided by RGD
Official Full Name: RAB31, member RAS oncogene familyprovided by RGD
Primary source: RGD:628598
See related: EnsemblRapid:ENSRNOG00000042189 AllianceGenome:RGD:628598
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rab0
Summary: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in Golgi vesicle transport. Located in early endosome; late endosome; and trans-Golgi network. Orthologous to human RAB31 (RAB31, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 198.3), Lung (RPKM 180.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q37

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (112693596..112828104, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (105246712..105382973, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (113370072..113504606, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data provide the first evidence for Rab22 (also known as Rab22b, Rab31) as a positive regulator of nerve growth factor (NGF) signal transduction and cell differentiation.
Title: Rab22 controls NGF signaling and neurite outgrowth in PC12 cells.
A developmental stage survey of the rat brain by Western immunoblot analysis indicated Rab22B presence at several stages of embryonic and postnatal development.
Title: Rab22B is expressed in the CNS astroglia lineage and plays a role in epidermal growth factor receptor trafficking in A431 cells.
Data demonstrate that Rab31 is required for transport of mannose 6-phosphate receptors from the trans-Golgi network to endosomes and for the Golgi/TGN organization.
Title: Transport of mannose-6-phosphate receptors from the trans-Golgi network to endosomes requires Rab31.

Submit: New GeneRIF Correction

General gene information

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Markers

RH132781 (e-PCR)
- UniSTS:216064

BE115592 (e-PCR)
- UniSTS:248178

D9Rat75 (e-PCR), detects polymorphism
- UniSTS:119195

RH132748 (e-PCR)
- UniSTS:216031

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GDP binding	IEA Inferred from Electronic Annotation more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GDP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to plasma membrane protein transport	IEA Inferred from Electronic Annotation more info
involved_in Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in Golgi to plasma membrane protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in Golgi vesicle transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phagosome maturation	IEA Inferred from Electronic Annotation more info
involved_in phagosome maturation	ISO Inferred from Sequence Orthology more info
involved_in phagosome maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phagocytosis, engulfment	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis, engulfment	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulated exocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulated exocytosis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in early phagosome membrane	IEA Inferred from Electronic Annotation more info
located_in early phagosome membrane	ISO Inferred from Sequence Orthology more info
located_in early phagosome membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic cup	IEA Inferred from Electronic Annotation more info
located_in phagocytic cup	ISO Inferred from Sequence Orthology more info
located_in phagocytic cup	ISS Inferred from Sequence or Structural Similarity more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
is_active_in trans-Golgi network membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ras-related protein Rab-31

Names: GTP-binding protein Rab0; monomeric GTP-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145094.2 → NP_659562.2 ras-related protein Rab-31

See identical proteins and their annotated locations for NP_659562.2

Status: PROVISIONAL

Source sequence(s)

BC072698

UniProtKB/Swiss-Prot

Q6GQP4, Q9JK74

UniProtKB/TrEMBL

A0A0G2JSZ1, A0A8I5Y4V8

Related

ENSRNOP00000063486.3, ENSRNOT00000067974.4

Conserved Domains (2) summary

cd01860
Location:6 → 168

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

pfam00071
Location:8 → 168

Ras; Ras family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

112693596..112828104 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039083027.2 → XP_038938955.1 ras-related protein Rab-31 isoform X1

Conserved Domains (1) summary

cl38936
Location:6 → 67

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases