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    Lpin2 lipin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316737, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Lpin2provided by RGD
    Official Full Name
    lipin 2provided by RGD
    Primary source
    RGD:1304588
    See related
    EnsemblRapid:ENSRNOG00000014876 AllianceGenome:RGD:1304588
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidate phosphatase activity and transcription coactivator activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; positive regulation of transcription by RNA polymerase II; and triglyceride biosynthetic process. Predicted to be active in cytosol; endoplasmic reticulum membrane; and nucleus. Human ortholog(s) of this gene implicated in chronic recurrent multifocal osteomyelitis. Orthologous to human LPIN2 (lipin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 124.7), Spleen (RPKM 111.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lpin2 in Genome Data Viewer
    Location:
    9q38
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (118529988..118604796)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (111083378..111158193)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (119517101..119591533)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555849 Neighboring gene U6 spliceosomal RNA Neighboring gene tRNA splicing endonuclease subunit 2, pseudogene 1 Neighboring gene U7 small nuclear RNA Neighboring gene elastin microfibril interfacer 2 Neighboring gene structural maintenance of chromosomes flexible hinge domain containing 1 Neighboring gene Y box binding protein 1, pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver. Kok BPC, et al. J Lipid Res, 2013 Jun. PMID 23505321, Free PMC Article
    2. A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2. Donkor J, et al. J Biol Chem, 2009 Oct 23. PMID 19717560, Free PMC Article
    3. Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns. Donkor J, et al. J Biol Chem, 2007 Feb 9. PMID 17158099
    4. Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2. Grimsey N, et al. J Biol Chem, 2008 Oct 24. PMID 18694939, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to insulin stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidate phosphatase LPIN2
    NP_001101706.1
    XP_006245724.1
    XP_006245725.1
    XP_006245726.1
    XP_006245727.1
    XP_038939723.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108236.1 → NP_001101706.1  phosphatidate phosphatase LPIN2

      See identical proteins and their annotated locations for NP_001101706.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474043
      UniProtKB/TrEMBL
      A0A8I5ZKH7, A6KF98, D3ZYB4
      Conserved Domains (5) summary
      PHA03247
      Location:326 → 483
      PHA03247; large tegument protein UL36; Provisional
      pfam04571
      Location:1 → 107
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:635 → 860
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam15017
      Location:873 → 891
      WRNPLPNID; Putative WW-binding domain and destruction box
      pfam16876
      Location:467 → 558
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      118529988..118604796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083795.1 → XP_038939723.1  phosphatidate phosphatase LPIN2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZKH7, A6KF98, D3ZYB4
      Related
      ENSRNOP00000020476.5, ENSRNOT00000020476.9
      Conserved Domains (5) summary
      PHA03247
      Location:326 → 483
      PHA03247; large tegument protein UL36; Provisional
      pfam04571
      Location:1 → 107
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:635 → 860
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam15017
      Location:873 → 891
      WRNPLPNID; Putative WW-binding domain and destruction box
      pfam16876
      Location:467 → 558
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    2. XM_006245662.5 → XP_006245724.1  phosphatidate phosphatase LPIN2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JY62, A0A8I5ZKH7
      Related
      ENSRNOP00000070532.1, ENSRNOT00000082005.3
      Conserved Domains (4) summary
      pfam15017
      Location:912 → 932
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:39 → 144
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:673 → 898
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:505 → 595
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    3. XM_006245665.5 → XP_006245727.1  phosphatidate phosphatase LPIN2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AH46
      Conserved Domains (4) summary
      pfam15017
      Location:861 → 881
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:39 → 144
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:673 → 847
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:505 → 595
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    4. XM_006245663.5 → XP_006245725.1  phosphatidate phosphatase LPIN2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZKH7
      Conserved Domains (4) summary
      pfam15017
      Location:911 → 931
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:39 → 144
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:672 → 897
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:504 → 594
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    5. XM_006245664.5 → XP_006245726.1  phosphatidate phosphatase LPIN2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZKH7
      Related
      ENSRNOP00000078237.2, ENSRNOT00000095983.2
      Conserved Domains (4) summary
      pfam15017
      Location:882 → 902
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:9 → 114
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:643 → 868
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:475 → 565
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    Nucleotide Protein Strain
    Heading Accession and Version

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