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    Impdh1 inosine monophosphate dehydrogenase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362329, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Impdh1provided by RGD
    Official Full Name
    inosine monophosphate dehydrogenase 1provided by RGD
    Primary source
    RGD:1311108
    See related
    EnsemblRapid:ENSRNOG00000020032 AllianceGenome:RGD:1311108
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    IMPD 1; IMPDH 1
    Summary
    Predicted to enable DNA binding activity; IMP dehydrogenase activity; and identical protein binding activity. Involved in retina development in camera-type eye. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Orthologous to human IMPDH1 (inosine monophosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 281.3), Adrenal (RPKM 210.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Impdh1 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (58767230..58782825, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (57801842..57817434, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (56478383..56493987, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 28 Neighboring gene proline-rich transmembrane protein 4 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134486744 Neighboring gene hypoxia inducible lipid droplet-associated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10). Tam LC, et al. Hum Mol Genet, 2008 Jul 15. PMID 18385099
    2. Synchronized changes in transcript levels of genes activating cold exposure-induced thermogenesis in brown adipose tissue of experimental animals. Watanabe M, et al. Biochim Biophys Acta, 2008 Jan. PMID 18036333
    3. Characterisation of inosine monophosphate dehydrogenase expression during retinal development: differences between variants and isoforms. Gunter JH, et al. Int J Biochem Cell Biol, 2008. PMID 18295529
    4. On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa. Aherne A, et al. Hum Mol Genet, 2004 Mar 15. PMID 14981049
    5. Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa. Bowne SJ, et al. Hum Mol Genet, 2002 Mar 1. PMID 11875050, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables IMP dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables IMP dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables IMP dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' XMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GTP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lymphocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within purine nucleotide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retina development in camera-type eye IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inosine-5'-monophosphate dehydrogenase 1
    Names
    IMP (inosine 5'-monophosphate) dehydrogenase 1
    IMP (inosine monophosphate) dehydrogenase 1
    IMP dehydrogenase 1
    inosine 5'-phosphate dehydrogenase 1
    NP_001102089.1
    NP_001385786.1
    XP_006236272.2
    XP_038963701.1
    XP_063142307.1
    XP_063142308.1
    XP_063142309.1
    XP_063142310.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108619.1 → NP_001102089.1  inosine-5'-monophosphate dehydrogenase 1 isoform 1

      See identical proteins and their annotated locations for NP_001102089.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473959
      UniProtKB/TrEMBL
      A0A8I6AI29, A6IEC0
      Conserved Domains (3) summary
      cd00381
      Location:86 → 527
      IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
      cd04602
      Location:172 → 264
      CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
      PTZ00314
      Location:71 → 544
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

    2. NM_001398857.1 → NP_001385786.1  inosine-5'-monophosphate dehydrogenase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      D3ZLZ7
      UniProtKB/TrEMBL
      A0A0A0MXZ8
      Conserved Domains (1) summary
      PTZ00314
      Location:14 → 510
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      58767230..58782825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286239.1 → XP_063142309.1  inosine-5'-monophosphate dehydrogenase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AC45

    2. XM_063286237.1 → XP_063142307.1  inosine-5'-monophosphate dehydrogenase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AC45

    3. XM_039107773.2 → XP_038963701.1  inosine-5'-monophosphate dehydrogenase 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AI29
      Related
      ENSRNOP00000027173.8, ENSRNOT00000027173.8
      Conserved Domains (1) summary
      PTZ00314
      Location:71 → 542
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

    4. XM_006236210.4 → XP_006236272.2  inosine-5'-monophosphate dehydrogenase 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AI29
      Related
      ENSRNOP00000095077.2, ENSRNOT00000110384.2
      Conserved Domains (1) summary
      PTZ00314
      Location:71 → 567
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

    5. XM_063286240.1 → XP_063142310.1  inosine-5'-monophosphate dehydrogenase 1 isoform X6

      UniProtKB/TrEMBL
      A0A0A0MXZ8

    6. XM_063286238.1 → XP_063142308.1  inosine-5'-monophosphate dehydrogenase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AC45
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZLZ7.1 GenPept UniProtKB/Swiss-Prot:D3ZLZ7

    Gene LinkOut

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