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    Ccnl2 cyclin L2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298686, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccnl2provided by RGD
    Official Full Name
    cyclin L2provided by RGD
    Primary source
    RGD:1309149
    See related
    EnsemblRapid:ENSRNOG00000018691 AllianceGenome:RGD:1309149
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in regulation of RNA splicing. Predicted to be located in nucleoplasm. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. Orthologous to human CCNL2 (cyclin L2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 300.9), Thymus (RPKM 292.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccnl2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171698951..171711037)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166416940..166428997)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173256301..173268279)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 65 Neighboring gene mitochondrial ribosomal protein L20 Neighboring gene uncharacterized LOC134487049 Neighboring gene uncharacterized LOC134487050 Neighboring gene aurora kinase A interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation. Chen HH, et al. Mol Cell Biol, 2006 Apr. PMID 16537916, Free PMC Article
    2. Characterization of cyclin L1 as an immobile component of the splicing factor compartment. Herrmann A, et al. FASEB J, 2007 Oct. PMID 17494991
    3. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-L2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401305.2 → NP_001388234.1  cyclin-L2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q5I0H5
      UniProtKB/TrEMBL
      A6IUS7

    2. NM_001401307.2 → NP_001388236.1  cyclin-L2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IUS8
      Related
      ENSRNOP00000025531.5, ENSRNOT00000025531.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      171698951..171711037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239544.5 → XP_006239606.1  cyclin-L2 isoform X1

      UniProtKB/TrEMBL
      A6IUS7
      Related
      ENSRNOP00000068952.3, ENSRNOT00000089936.3
      Conserved Domains (2) summary
      cd20590
      Location:33 → 188
      CYCLIN_CCNL2_rpt1; first cyclin box found in cyclin-2 (CCNL2) and similar proteins
      cd20593
      Location:193 → 315
      CYCLIN_CCNL2_rpt2; second cyclin box found in cyclin-2 (CCNL2) and similar proteins

    2. XM_039109721.2 → XP_038965649.1  cyclin-L2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y5M3
      Related
      ENSRNOP00000077305.2, ENSRNOT00000096422.2
      Conserved Domains (2) summary
      cd20593
      Location:168 → 290
      CYCLIN_CCNL2_rpt2; second cyclin box found in cyclin-2 (CCNL2) and similar proteins
      cl40454
      Location:33 → 163
      CYCLIN_SF; Cyclin box fold superfamily

    3. XM_063287498.1 → XP_063143568.1  cyclin-L2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y5M3

    4. XM_063287500.1 → XP_063143570.1  cyclin-L2 isoform X5

    5. XM_063287499.1 → XP_063143569.1  cyclin-L2 isoform X4

    RNA

    1. XR_005504417.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5I0H5.2 GenPept UniProtKB/Swiss-Prot:Q5I0H5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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