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    Zbtb5 zinc finger and BTB domain containing 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298084, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zbtb5provided by RGD
    Official Full Name
    zinc finger and BTB domain containing 5provided by RGD
    Primary source
    RGD:1307367
    See related
    EnsemblRapid:ENSRNOG00000012726 AllianceGenome:RGD:1307367
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZBTB5 (zinc finger and BTB domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 53.4), Thymus (RPKM 47.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zbtb5 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (64039805..64062451, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (59244132..59265461, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (60538926..60561487, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102863 Neighboring gene glyoxylate and hydroxypyruvate reductase Neighboring gene uncharacterized LOC134486934 Neighboring gene RNA polymerase I subunit E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel POK family transcription factor, ZBTB5, represses transcription of p21CIP1 gene. Koh DI, et al. J Biol Chem, 2009 Jul 24. PMID 19491398, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106657.1 → NP_001100127.1  zinc finger and BTB domain-containing protein 5

      See identical proteins and their annotated locations for NP_001100127.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473962
      UniProtKB/TrEMBL
      A6IJ82, D3ZFS3
      Related
      ENSRNOP00000100131.1, ENSRNOT00000144971.1
      Conserved Domains (3) summary
      sd00017
      Location:608 → 628
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18196
      Location:3 → 128
      BTB_POZ_ZBTB5; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5)
      pfam13465
      Location:622 → 645
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      64039805..64062451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287335.1 → XP_063143405.1  zinc finger and BTB domain-containing protein 5 isoform X1

      UniProtKB/TrEMBL
      A6IJ82, D3ZFS3

    2. XM_006238048.5 → XP_006238110.1  zinc finger and BTB domain-containing protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006238110.1

      UniProtKB/TrEMBL
      A6IJ82, D3ZFS3
      Related
      ENSRNOP00000098901.1, ENSRNOT00000135058.1
      Conserved Domains (3) summary
      sd00017
      Location:608 → 628
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18196
      Location:3 → 128
      BTB_POZ_ZBTB5; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5)
      pfam13465
      Location:622 → 645
      zf-H2C2_2; Zinc-finger double domain

    3. XM_063287334.1 → XP_063143404.1  zinc finger and BTB domain-containing protein 5 isoform X1

      UniProtKB/TrEMBL
      A6IJ82, D3ZFS3

    4. XM_063287333.1 → XP_063143403.1  zinc finger and BTB domain-containing protein 5 isoform X1

      UniProtKB/TrEMBL
      A6IJ82, D3ZFS3

    5. XM_006238047.5 → XP_006238109.1  zinc finger and BTB domain-containing protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006238109.1

      UniProtKB/TrEMBL
      A6IJ82, D3ZFS3
      Related
      ENSRNOP00000104376.1, ENSRNOT00000148065.1
      Conserved Domains (3) summary
      sd00017
      Location:608 → 628
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18196
      Location:3 → 128
      BTB_POZ_ZBTB5; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5)
      pfam13465
      Location:622 → 645
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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