Hrc histidine rich calcium binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hrcprovided by RGD
Official Full Name: histidine rich calcium binding proteinprovided by RGD
Primary source: RGD:727864
See related: EnsemblRapid:ENSRNOG00000020719 AllianceGenome:RGD:727864
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ATPase binding activity; calcium ion binding activity; and transmembrane transporter binding activity. Involved in negative regulation of calcium ion import into sarcoplasmic reticulum and negative regulation of cytosolic calcium ion concentration. Predicted to be located in Z disc and sarcoplasmic reticulum membrane. Orthologous to human HRC (histidine rich calcium binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 397.7) and Heart (RPKM 259.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (104949750..104953475)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (95813262..95816987)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (101324788..101328391)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure and expression of the mammalian HRC gene, together with the comparative expression data of the related sarcoplasmic reticulum genes.
Title: Complementary DNA cloning, genomic characterization and expression analysis of a mammalian gene encoding histidine-rich calcium binding protein.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium ion import into sarcoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of relaxation of cardiac muscle	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell communication by electrical coupling involved in cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in regulation of ryanodine-sensitive calcium-release channel activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sarcoplasmic reticulum histidine-rich calcium-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181369.3 → NP_852034.2 sarcoplasmic reticulum histidine-rich calcium-binding protein precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6JB08, G3V8S6, Q80W59

Related

ENSRNOP00000028116.3, ENSRNOT00000028116.7