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    Plcd3 phospholipase C, delta 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287745, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Plcd3provided by RGD
    Official Full Name
    phospholipase C, delta 3provided by RGD
    Primary source
    RGD:1310903
    See related
    EnsemblRapid:ENSRNOG00000003033 AllianceGenome:RGD:1310903
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol phospholipase C activity. Predicted to be involved in intracellular signal transduction and lipid catabolic process. Predicted to act upstream of or within angiogenesis; labyrinthine layer blood vessel development; and regulation of cell population proliferation. Predicted to be located in nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human PLCD3 (phospholipase C delta 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 74.8), Adrenal (RPKM 36.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plcd3 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (88526802..88548116, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (88026707..88048080, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (91164778..91186067, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene complement C1q like 1 Neighboring gene dephospho-CoA kinase domain containing Neighboring gene N-myristoyltransferase 1 Neighboring gene acyl-CoA binding domain containing 4 Neighboring gene HEXIM P-TEFb complex subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Localization of phospholipase C delta3 in the cell and regulation of its activity by phospholipids and calcium. Pawelczyk T, et al. Eur J Biochem, 1998 Oct 1. PMID 9799116
    2. Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy. Nakamura Y, et al. Cell Death Dis, 2014 May 8. PMID 24810051, Free PMC Article
    3. Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development. Nakamura Y, et al. Mol Cell Biol, 2005 Dec. PMID 16314520, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate that PLCdelta1 and PLCdelta3 are required for cardiomyocyte survival and normal cardiac function.
      Title: Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within labyrinthine layer blood vessel development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
    NP_001099315.3
    XP_017452628.1
    XP_017452629.1
    XP_017452631.1
    XP_038941555.1
    XP_038941556.1
    XP_038941557.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105845.3 → NP_001099315.3  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D4A978
      Related
      ENSRNOP00000112234.1, ENSRNOT00000149994.1
      Conserved Domains (4) summary
      cd08630
      Location:332 → 627
      PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3
      PLN02228
      Location:251 → 783
      PLN02228; Phosphoinositide phospholipase C
      cd13363
      Location:61 → 177
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam14788
      Location:197 → 246
      EF-hand_10; EF hand

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      88526802..88548116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085627.2 → XP_038941555.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1

      UniProtKB/TrEMBL
      D4A978
      Conserved Domains (4) summary
      PLN02228
      Location:251 → 782
      PLN02228; Phosphoinositide phospholipase C
      cd13363
      Location:61 → 177
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam14788
      Location:197 → 246
      EF-hand_10; EF hand
      cl14615
      Location:332 → 626
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    2. XM_017597142.3 → XP_017452631.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X3

      UniProtKB/TrEMBL
      D4A978
      Conserved Domains (4) summary
      cd08630
      Location:272 → 567
      PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3
      PLN02228
      Location:191 → 723
      PLN02228; Phosphoinositide phospholipase C
      cd13363
      Location:1 → 117
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam14788
      Location:137 → 186
      EF-hand_10; EF hand

    3. XM_017597139.3 → XP_017452628.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AGE0, D4A978
      Related
      ENSRNOP00000091874.1, ENSRNOT00000099178.2

    4. XM_017597140.3 → XP_017452629.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AGE0, D4A978

    5. XM_039085628.2 → XP_038941556.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X3

      UniProtKB/TrEMBL
      D4A978
      Conserved Domains (4) summary
      cd08630
      Location:272 → 567
      PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3
      PLN02228
      Location:191 → 723
      PLN02228; Phosphoinositide phospholipase C
      cd13363
      Location:1 → 117
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      pfam14788
      Location:137 → 186
      EF-hand_10; EF hand

    6. XM_039085629.2 → XP_038941557.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X4

      Conserved Domains (3) summary
      cd13363
      Location:61 → 177
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      cd16218
      Location:182 → 320
      EFh_PI-PLCdelta3; EF-hand motif found in phosphoinositide phospholipase C delta 3 (PI-PLC-delta3)
      cl14615
      Location:332 → 605
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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