Scn3b sodium voltage-gated channel beta subunit 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Scn3bprovided by RGD
Official Full Name: sodium voltage-gated channel beta subunit 3provided by RGD
Primary source: RGD:621657
See related: EnsemblRapid:ENSRNOG00000057221 AllianceGenome:RGD:621657
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Scnb3
Summary: Predicted to enable sodium channel inhibitor activity; transmembrane transporter binding activity; and voltage-gated sodium channel activity involved in cardiac muscle cell action potential. Involved in nervous system development and sodium ion transport. Predicted to be located in Z disc and plasma membrane. Predicted to be part of voltage-gated sodium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 7. Orthologous to human SCN3B (sodium voltage-gated channel beta subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 199.0), Lung (RPKM 195.3) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (49527529..49550019)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (40630372..40652869)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (44136413..44159011)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the presences of Nav1.1, Nav1.6, Navbeta1 and Navbeta3 mRNA and their reduced levels in rat SAN during aging.
Title: Age-dependent alterations of voltage-gated Na(+) channel isoforms in rat sinoatrial node.
The sodium channel {beta}3-subunit induces multiphasic gating in NaV1.3 and affects fast inactivation via distinct intracellular regions.
Title: The sodium channel {beta}3-subunit induces multiphasic gating in NaV1.3 and affects fast inactivation via distinct intracellular regions.
that sodium channel Na(v)1.1, Na(v)1.3 and beta(1) subunit up-regulation at the mRNA and protein levels of SER hippocampus might contribute to the generation of epileptiform activity and underlie the observed seizure phenotype in SER.
Title: Voltage-gated sodium channel Nav1.1, Nav1.3 and beta1 subunit were up-regulated in the hippocampus of spontaneously epileptic rat.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables sodium channel inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SA node cell action potential	ISO Inferred from Sequence Orthology more info
involved_in atrial cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell action potential involved in contraction	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during cardiac muscle cell action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane depolarization during cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of atrial cardiac muscle cell membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in ventricular cardiac muscle cell action potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of voltage-gated sodium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated sodium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium channel regulatory subunit beta-3; sodium channel subunit beta-3

Names: sodium channel beta 3 subunit; sodium channel, voltage-gated, type III, beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139097.3 → NP_620797.1 sodium channel regulatory subunit beta-3 precursor

See identical proteins and their annotated locations for NP_620797.1

Status: PROVISIONAL

Source sequence(s)

BC070899

UniProtKB/Swiss-Prot

Q9JK00

UniProtKB/TrEMBL

A6J3Q2

Related

ENSRNOP00000071448.1, ENSRNOT00000087022.3

Conserved Domains (2) summary

pfam07686
Location:28 → 122

V-set; Immunoglobulin V-set domain

cd00096
Location:31 → 37

Ig; Ig strand A' [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

49527529..49550019

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063264913.1 → XP_063120983.1 sodium channel subunit beta-3 isoform X1

UniProtKB/Swiss-Prot

Q9JK00

UniProtKB/TrEMBL

A6J3Q2
XM_063264914.1 → XP_063120984.1 sodium channel subunit beta-3 isoform X1

UniProtKB/Swiss-Prot

Q9JK00

UniProtKB/TrEMBL

A6J3Q2
XM_039080819.2 → XP_038936747.1 sodium channel subunit beta-3 isoform X2

Conserved Domains (2) summary

pfam07686
Location:2 → 82

V-set; Immunoglobulin V-set domain

cd00096
Location:33 → 38

Ig; Ig strand C' [structural motif]
XM_017595466.2 → XP_017450955.1 sodium channel subunit beta-3 isoform X2

Related

ENSRNOP00000109471.1, ENSRNOT00000158727.1

Conserved Domains (2) summary

pfam07686
Location:2 → 82

V-set; Immunoglobulin V-set domain

cd00096
Location:33 → 38

Ig; Ig strand C' [structural motif]
XM_006243102.3 → XP_006243164.1 sodium channel subunit beta-3 isoform X1

See identical proteins and their annotated locations for XP_006243164.1

UniProtKB/Swiss-Prot

Q9JK00

UniProtKB/TrEMBL

A6J3Q2

Conserved Domains (2) summary

pfam07686
Location:28 → 122

V-set; Immunoglobulin V-set domain

cd00096
Location:31 → 37

Ig; Ig strand A' [structural motif]
XM_006243103.3 → XP_006243165.1 sodium channel subunit beta-3 isoform X1

See identical proteins and their annotated locations for XP_006243165.1

UniProtKB/Swiss-Prot

Q9JK00

UniProtKB/TrEMBL

A6J3Q2

Conserved Domains (2) summary

pfam07686
Location:28 → 122

V-set; Immunoglobulin V-set domain

cd00096
Location:31 → 37

Ig; Ig strand A' [structural motif]
XM_063264915.1 → XP_063120985.1 sodium channel subunit beta-3 isoform X2