URH1 trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: URH1
Official Full Name: trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase
Primary source: SGD:S000002808
Locus tag: YDR400W
See related: AllianceGenome:SGD:S000002808; FungiDB:YDR400W; VEuPathDB:YDR400W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables nicotinamide riboside hydrolase activity; nicotinic acid riboside hydrolase activity; and uridine nucleosidase activity. Involved in pyridine nucleotide biosynthetic process; pyrimidine ribonucleoside catabolic process; and pyrimidine-containing compound salvage. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See URH1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1271063..1272085)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mechanism of action of nicotinamide riboside is totally dependent on increased net NAD synthesis through two pathways, the Nrk1 pathway and the Urh1/Pnp1/Meu1 pathway, which is Nrk1 independent.
Title: Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing N-glycosyl compounds	IEA Inferred from Electronic Annotation more info
enables nicotinamide riboside hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables nicotinic acid riboside hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables purine nucleosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosylpyrimidine nucleosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables uridine nucleosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables uridine nucleosidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NAD biosynthesis via nicotinamide riboside salvage pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cytidine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nicotinate nucleotide salvage	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleoside catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyrimidine nucleoside catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in pyrimidine-containing compound salvage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in uridine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase

NP_010688.4

EC 3.2.2.3

Uridine nucleosidase (uridine-cytidine N-ribohydrolase); cleaves N-glycosidic bonds in nucleosides; dual roles in NAD+ biosynthesis and the nucleobase salvage pathway; monomeric structure unique to this class of enzymes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1271063..1272085

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180708.3 → NP_010688.4 TPA: trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010688.4

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VT33, Q04179

UniProtKB/TrEMBL

A6ZZ00, G2WBD9, N1PAJ4

Conserved Domains (1) summary

cd02651
Location:7 → 330

nuc_hydro_IU_UC_XIUA; inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These ...